Abstract
Hormone therapy of metastatic prostate cancer (mPC) has been the “golden standard” of treatment since 1941. However, survival rates in patients with this pathology have remained low. Based on the results of newer studies, early start of docetaxel chemotherapy or antiandrogen abiraterone therapy in combination with standard hormone therapy allows to significantly increase survival of patients with mPC. In this review, data from these studies and advisability of docetaxel and abiraterone at the 1st line therapy of mPC are discussed.
Highlights
Current approaches to selection of the 1st line therapy in patients with metastatic hormone-sensitive prostate cancer B.Ya
Данные ряда доклинических исследований показывают, что таксаны влияют и на андрогензависимые сигнальные пути за счет блокировки транслокации рецепторов в ядра клеток и последующей экспрессии их генов-эффекторов [10,11,12]
Последовательность терапии На основании данных рандомизированных исследований как доцетаксел, так и абиратерон в комбинации со стандартной антиандрогенной терапии (ААТ) являются «золотым стандартом» лечения больных мГЧРПЖ
Summary
Current approaches to selection of the 1st line therapy in patients with metastatic hormone-sensitive prostate cancer B.Ya. Анализ результатов лечения 80 больных мРПЖ в клинических исследованиях National Cancer Institute показал, что медиана времени до развития кастрационно-рефрактерного мРПЖ (мКРРПЖ) у больных с наличием метастазов на момент начала антиандрогенной терапии (ААТ) и без них составила 13,1 и 19,3 мес соответственно [5].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
