Curative effect of ulinastatin on brain injury and prognosis of cardiopulmonary resuscitation

Abstract

Objective To study the therapeutic effect of ulinastatin on brain injury and prognosis of cardiopulmonary resuscitation. Methods A total of 84 cases in the emergency department were randomly divided into routine treatment group (group A) and ulinastatin treatment group (group B), with 42 cases in each group. The Glasgow Coma Scale (GCS), acute physiology and chronic health score (APACHE-Ⅱ) were performed at 1 d (T1), 3 D (T2), 7 d (T3), and acute physiology and chronic health score (GCS), respectively after cardiopulmonary resuscitation (CPR) and resuscitation (T0) and resuscitation. The incidence of hospitalization time, mechanical ventilation time, mortality and multiple organ dysfunction syndrome (MODS) were recorded in the two groups. Results At T0, T1, the GCS had no significant difference between the two groups(P>0.05); at T2, T3, there was significant difference between the two groups (P 0.05), APACHE-Ⅱ of T3 was significantly lower than that of T1 (P 0.05), group B were significantly lower than group A at T3, the difference was significant (P<0.05). The two groups had significant differences in hospitalization time and mechanical ventilation time (P<0.05), the fatality and incidence of MODS in group B were lower than those in group A, the differences were significant (P< 0.05). Conclusions Ulinastatin in treatment of brain injury after cardiopulmonary resuscitation can shorten the hospitalization time, increase the survival rate of the patients, improve the prognosis of patients, has good treatment effect. Key words: Ulinastatin; Cardiopulmonary resuscitation; Brain injury