Abstract
P92 Introduction: Coronary artery calcification (CAC) by electron beam computed tomography (EBCT) is associated with contemporaneous levels of traditional risk factors (RFs). The availability of repeated measures over 25 years allows a unique examination of relations of CAC with long-term RF levels in Framingham Heart Study subjects. Methods: Men and women free of symptomatic coronary disease underwent EBCT. Subjects were randomly sampled across quartiles of age and quintiles of Framingham coronary risk score. Longterm RFs were derived from 25-year averaged values. Logistic regression was used to relate long-term RFs to CAC. Results: In 167 men (35-76 yrs) and 160 women (35-77 yrs), age, long-term total cholesterol, and long-term systolic BP were related to Agatston CAC score ≥ 100 ( Table). In multivariable analyses, long-term total cholesterol was an independent predictor of CAC (p<0.02). Conclusion: Long-term exposure to coronary disease RFs is associated with increased risk for subclinical CAC. These studies may provide insights into differences in RFs for clinical coronary events and for atherosclerosis. Table 1.
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