Cu-Vit B3 MOF solvothermal preparation, characterization and evaluation as HIV-1 RNA replication inhibitor

Abstract

Cu-based metal-organic framework (Cu-Vit B3 MOF) was solvothermal synthesized and produced mesoporous nanostructures and fully characterized by scanning electron microscope (SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and Transmission electron microscope (TEM) to determine the surface topology, copper content, crystal structure, functional groups and particles size of Cu-MOF, respectively. AIDS virus is classified as one of the most vicious viruses while RNA replication by translational frameshifting is the main ring in the replication cycle of HIV. Frameshifting is needed for the viral Pol protein synthesis so drug molecules that target this step can inhibit HIV replication. The synthesized MOF was evaluated as an HIV replication inhibitor by binding to HIV-1 Frameshift Site RNA, transcriptase and integrase. The obtained data explained that the prepared Cu-Vit B3 MOF gave auspicious positive results compared with reference drugs Dolutegravir (DTG) and Nevirapine (NVP). And so, this class of organometallic compounds can be presented as a potent HIV replication inhibitor.