Abstract
Background: CTRP1, a recently identified adipokine, was found to stimulate aldosterone production. Serum CTRP1 and plasma Aldosterone levels were significantly increased in patients with diabetes mellitus and metabolic syndrome. Therefore, it would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with hypertension as well as with diabetes mellitus. Aim: This study evaluated serum CTRP1 and aldosterone concentrations in healthy individuals and in patients with diabetic nephropathy. Methods: Serum samples from 32 healthy individuals and 44 patients with diabetic nephropathy were measured for CTRP1, Aldosterone, diabetes-related biomarkers and renal disease-related biomarkers by enzyme-linked immunosorbent assay (ELISA). Results: Correlation analyses showed that serum CTRP1 in healthy individuals was not correlated with any other biochemical parameters or laboratory characteristic; however, in patients with diabetic nephropathy, a significant correlation was found between serum CTRP1 and Aldosterone (P=0.003), Urea, Cystatin C and ANGPTL4. Aldosterone level was significantly higher in subjects with diabetic nephropathy compared to healthy subjects (P=0.01). Discussion: Our results demonstrated that the adipokine CTRP1 is significantly associated with Aldosterone and support the hypothesis that CTRP1 may be a newly identified molecular link between obesity and hypertension.
Highlights
CTRP1 (Complement C1q tumor necrosis factor-related protein 1, FLJ90694, GIP, G protein-coupled receptor-interacting protein, UNQ310/PRO353, ZSIG37) is localized to human chromosome 17 and is primarily expressed from cells in the stroma vascular fraction of adipose tissue and is expressed in the zona glomerulosa of the adrenal cortex and in vascular wall tissue [1,2]
Correlation analyses showed that serum CTRP1 in healthy individuals was not correlated with any other biochemical parameters or laboratory characteristic; in patients with diabetic nephropathy, a significant correlation was found between serum CTRP1 and Aldosterone (P=0.003), Urea, Cystatin C and ANGPTL4
Previous studies identified that the level of CTRP1 is increased in the blood of hypertensive patients, as aldosterone production was stimulated by CTRP1 [1]
Summary
CTRP1 (Complement C1q tumor necrosis factor-related protein 1, FLJ90694, GIP, G protein-coupled receptor-interacting protein, UNQ310/PRO353, ZSIG37) is localized to human chromosome 17 and is primarily expressed from cells in the stroma vascular fraction of adipose tissue and is expressed in the zona glomerulosa of the adrenal cortex and in vascular wall tissue [1,2]. It is a 35 kDa secreted glycoprotein [3] that is a member of the CTRP superfamily [1]. It would be interesting to investigate whether the secretion of CTRP1 in human serum is associated with hypertension as well as with diabetes mellitus
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