Abstract
BackgroundThe aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP).MethodsTwo hundred ninety-nine people suffering from AP and 417 healthy volunteers were subjected to the study. DNA was isolated from blood samples.ResultsCTRC p.G60 = polymorphism (c.180C > T) occurred more frequently in the AP group (p = 0.015). The CT and TT genotype was found in 27.8% of the AP patients and in 19.9% of the healthy subjects (p = 0.017). No significant correlation was found between having the CT and TT genotype and the severity of the AP clinical course. In 6 patients (2%) with the CT genotype, a SPINK1 gene mutation was found, while in the control group it was found in 3 patients (0.7%), (p > 0.05). All patients with the present SPINK1 mutation with the CT genotype had a moderate or a severe course of the disease (p = 0.0007).ConclusionsCTRC polymorphism Hetero p.G60=; c.180C > T increases the risk of an AP occurrence and together with the SPINK 1 mutation, may be responsible for a more severe course of the disease.
Highlights
The aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) chymotrypsin C (CTRC) and the incidence together with the clinical course of acute pancreatitis (AP)
The most common causes of AP include cholelithiasis and alcohol consumption, some studies point to the importance of genetic mutations and polymorphisms [3,4,5,6]
The computed tomography (CT) and TT genotype was found in 27.8% of the AP patients and in 19.9% of the healthy subjects (p = 0.017)
Summary
The aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP). A higher incidence of acute pancreatitis (AP) has been reported in many countries. The most common causes of AP include cholelithiasis and alcohol consumption, some studies point to the importance of genetic mutations and polymorphisms [3,4,5,6]. Such an approach indicates a complex and multifactorial nature of acute pancreatitis. There is no long term follow-up that
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