Abstract
Background An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a negative regulator of T cell activation [2] expressed in placental fibroblasts and may modulate peripheral selftolerance of the allogenic fetus [3,4]. It is a stimulatory molecule involved in T-cell activation at the maternal– fetal interface in women with unexplained pregnancy loss [5,6]. In this study, we investigate the possible associations of Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with idiopathic recurrent pregnancy loss (RPL).
Highlights
An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]
The distribution of rs231775 (P
Among the six three-locus Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) haplotypes constructed, increased frequency of CGA (P=0.0046), and CAG (P=0.036) haplotypes were seen in RPL cases, conferring disease susceptibility nature to these haplotypes
Summary
An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a negative regulator of T cell activation [2] expressed in placental fibroblasts and may modulate peripheral selftolerance of the allogenic fetus [3,4]. It is a stimulatory molecule involved in T-cell activation at the maternal– fetal interface in women with unexplained pregnancy loss [5,6]. Among the six three-locus CTLA-4 haplotypes constructed (rs5742909/rs231775/rs3087243), increased frequency of CGA (P=0.0046), and CAG (P=0.036) haplotypes were seen in RPL cases, conferring disease susceptibility nature to these haplotypes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
