Abstract
Background: To examine for relationships between neurotransmitters and personality. Method: 27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ). Result: CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores. Conclusion: Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression. Limitation: The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.
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