Abstract
17-β-Estradiol or cholesterol was subcutaneously implanted in bilaterally oophorectomized rhesus monkeys for 37 days, after which the pituitary glands were analyzed ultrastructurally for evidence of granule disposal. Plasma estrogen returned to a physiologic level of 97.6 ± 2.8 pg/ml in the estrogen-treated animals but not in the cholesterol-treated controls. The hypertrophied gonadotrophs in the controls contained numerous large vesicles and a few secretory granules. The gonadotrophs in the experimental animals showed a reduction in cell size, a diminution of the dilated endoplasmic reticulum, and an accumulation of secretory granules. Moreover, crystalline inclusions composed of parallel and orthogonally arranged fibers were present in some gonadotrophs, most frequently in animals with lower levels of circulating estrogen. These inclusions are thought to be involved in the process of intracellular secretion in monkeys.
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