Abstract
In the title mol-ecular salt, C26H24N3S+·Br-, the dihedral angles between the thia-zole ring and its attached phenyl and benzoyl rings are 54.81 (7) and 85.51 (7)°, respectively. In the crystal, ion pairs are linked by C-H⋯Br and N-H⋯Br hydrogen bonds and are connected into helical chains extending along the c-axis direction by weak, electrostatic S⋯Br- inter-actions. A Hirshfeld surface analysis was performed, which showed the dominant role of H⋯H contacts (51.3%).
Highlights
Thiazoles are a class of heterocyclic compounds found in many biologically active drugs such as sulfathiazol, ritonavir, abafungin and tiazofurin (Siddiqui et al, 2009)
As with many biologically active molecules, the molecular conformation adopted may have a significant effect on the activity which prompted an examination of the crystal structure of the title salt, C26H24N3SÁBr, I (Fig. 1)
Structural commentary As expected, the C11/C12/C13/N3/S1 thiazole ring in I is almost planar (r.m.s. deviation = 0.0056 A ) and the mean planes of the C14–C19 and C21–C26 benzene rings are inclined to this plane by 54.81 (7) and 85.51 (7), respectively
Summary
Thiazoles are a class of heterocyclic compounds found in many biologically active drugs such as sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (antifungal drug) and tiazofurin (antineoplastic drug) (Siddiqui et al, 2009). Other compounds containing the thiazole or thiazolyl moiety show numerous biological activities such as antimicrobial and antifungal (Vasu et al, 2013), anti-inflammatory (Singh et al, 2008), anticancer (Luzina et al, 2009), antihypertensive (Turan-Zitouni et al, 2000), anti-HIV (Rawal et al, 2008), anticonvulsant (Satoh et al, 2009) and antidiabetic properties (Iino et al, 2009). As with many biologically active molecules, the molecular conformation adopted may have a significant effect on the activity which prompted an examination of the crystal structure of the title salt, C26H24N3SÁBr, I (Fig. 1). Symmetry code: (i) x; Ày þ 1; z À 12
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