Abstract
We report a case of an immunocompetent Peruvian patient from the Andes with a one-month history of meningoencephalitis. Cryptococcus gattii was identified from a cerebrospinal fluid culture through assimilation of D-proline and D-tryptophan as the single nitrogen source. Initially, the patient received intravenous antifungal therapy with amphotericin B. The patient was discharged 29 days after hospitalization and continued with oral fluconazole treatment for ten weeks. During this period, the patient showed clinical improvement with slight right-side residual weakness. Through this case report, we confirm the existence of this microorganism as an infectious agent in Peru.
Highlights
Cryptococcus neoformans is subdivided in three varieties and five serotypes: Cryptococcus grubii, Cryptococcus neoformans and Cryptococcus gattii[1]
Meningoencephalitis caused by C. gattii in apparently immunocompetent HIV-seronegative individuals occurs throughout tropical latitudes, and in parts of South-East Asia and Australia[1]
In Peru, it is known that C. gattii produces infection in humans, and this has previously been reported in the literature[2]
Summary
Cryptococcus neoformans is subdivided in three varieties and five serotypes: Cryptococcus grubii (serotype A), Cryptococcus neoformans (serotypes D and AD) and Cryptococcus gattii (serotypes B and C)[1]. 2. Institute of Tropical Medicine, National University of San Marcos, Lima, Peru. In Peru, it is known that C. gattii produces infection in humans, and this has previously been reported in the literature[2]. We present a report on meningoencephalitis due to C. gattii in an HIV-negative patient who was from the Andes.
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