Abstract
Drug-diffusion kinetics in 2-hydroxyethyl methacrylate hydrogels were studied as a function of the crosslinking density and porosity. By varying the concentration of the crosslinker, tetraethylene glycol dimethacrylate, we demonstrated how the release of Timolol maleate could be optimized to allow for efficient drug delivery. FTIR and spectrophotometry supplied optical inferences into the functional groups present. By studying the swelling and degradation of hydrogels, supplemented with drug-release kinetics studies, the relationship between these two tenets could be formulated.
Highlights
The human eye is debilitated by various diseases, including glaucoma
Glaucoma is an eye disease which creates an increase in interocular pressure (IOP), which can lead to vision loss or, in extreme cases, blindness [3]
One could develop a high-volume controllable system. This would allow for an efficient and consistent release of medication, as is more desirable for a commercial product. It was demonstrated how glaucoma could be treated by using a Timololcontaining drug-delivery vehicle
Summary
The human eye is debilitated by various diseases, including glaucoma. In 2010, it was suggested that 60.5 million people worldwide would suffer from open-angle glaucoma (OAG) or angular-closure glaucoma (ACG). A distinction present in glaucoma is that 50% of those with the disease are not aware of having it. This is due to the inherent lack in the presentation of symptoms of the disease [2]. Glaucoma is an eye disease which creates an increase in interocular pressure (IOP), which can lead to vision loss or, in extreme cases, blindness [3]. A medication used to treat glaucoma is Timolol maleate, or Timolol. It falls under the categorization of a beta-blocker and treats glaucoma through reducing the IOP by reducing the aqueous humor secretion in the body [4]
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