Cross-category attentional biases driven by visual mental imagery of social cues.

A common and specialized neural code for social attention triggered by eye gaze and biological motion

Previous evidence suggests that directional social cues (e.g., eye gaze) cause automatic shifts in attention toward gaze direction. It has been proposed that automatic attentional orienting driven by social cues (social orienting) involves a different neural network from automatic orienting driven by nonsocial cues. However, previous neuroimaging studies on social orienting have only compared gaze cues to symbolic cues, which typically engage top-down mechanisms. Therefore, we directly compared the neural activity involved in social orienting to that involved in purely automatic nonsocial orienting. Twenty participants performed a spatial cueing task consisting of social (gaze) cues and automatic nonsocial (peripheral squares) cues presented at short and long stimulus (cue-to-target) onset asynchronies (SOA), while undergoing fMRI. Behaviorally, a facilitation effect was found for both cue types at the short SOA, while an inhibitory effect (inhibition of return: IOR) was found only for nonsocial cues at the long SOA. Imaging results demonstrated that social and nonsocial cues recruited a largely overlapping fronto-parietal network. In addition, social cueing evoked greater activity in occipito-temporal regions at both SOAs, while nonsocial cueing recruited greater subcortical activity, but only for the long SOA (when IOR was found). A control experiment, including central arrow cues, confirmed that the occipito-temporal activity was at least in part due to the social nature of the cue and not simply to the location of presentation (central vs. peripheral). These results suggest an evolutionary trajectory for automatic orienting, from predominantly subcortical mechanisms for nonsocial orienting to predominantly cortical mechanisms for social orienting.

Atypical neural networks for social orienting in autism spectrum disorders

Humans are highly adept at utilizing various social signals, such as eye gaze and biological motion (BM), to detect important events (e.g. threat, reward) in the environment, a phenomenon termed social attention. Here we investigated whether the affective information carried by the contextual event would modulate this social attention behaviour. By introducing natural emotional pictures (negative, neutral and positive) as peripheral probing targets within the modified central cueing paradigm, we found that central BM induced a stronger attentional orienting effect towards negative targets than neutral and positive ones. Moreover, this modulation was observed in attentional effects induced by another well-known social cue (i.e. eye gaze), whereas no such effect was obtained with the non-social arrow cues. Importantly, this negativity bias persisted at the subliminal level, as shown by the significant attentional effects towards negative targets induced by unconscious social cues (i.e. BM, eye gaze). In contrast, no attentional effects were obtained with non-conscious arrow cues. Overall, these findings reveal a general enhancement of negative targets on conscious and unconscious social attention induced by different types of social signals (i.e. BM, eye gaze) and highlight the distinction of social attention compared to non-social attention in detecting potentially detrimental events.

Visual mental imagery of nonpredictive central social cues triggers automatic attentional orienting

The attentional orienting induced by social cues, such as eye gaze and walking direction of biological motion, plays a vital role in human survival and interpersonal interactions. It has long been debated whether this indispensable ability is unique and intrinsically distinct from nonsocial attention. In the current study, we characterized the temporal profiles of the attentional orienting triggered by social cues (i.e., eye gaze and walking direction) and compared them with those induced by nonsocial cues (i.e., arrows) and exogenous cues using a covert orienting task. We calculated the attentional cuing effects in the early and the late periods of the task and further carried out a time course analysis to characterize their dynamic changes over trials. Whereas the cuing effect induced by nonsocial cues exhibited a significant trend of temporal decay, the cuing effects induced by the two different social cues were similar and remained stable throughout the task, resembling that induced by reflexive exogenous cues. These results clearly demonstrate that the socially coordinated attentional orienting is a highly reflexive and temporally stable response, which is less susceptible to top-down cognitive control and substantially distinguished from the attentional orienting induced by nonsocial cues. These findings extend our understandings of the distinction between social and nonsocial attention and further substantiate the specificity of social attentional orienting from a temporal-stability perspective. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Schizophrenia is associated with impairments in social motivation. Social attention has been proposed as an underlying mechanism for social motivation. However, studies in schizophrenia have rarely examined social attention, and none of these studies examined the effects with rapidly presented stimuli. The current study examined whether individuals with schizophrenia have reduced social attention and whether reduced social attention was related to social motivation deficits (measured with the Clinical Assessment Interview for Negative Symptoms) and decreased social functioning (Role Functioning Scale). Thirty-seven outpatients with schizophrenia and 29 healthy participants completed a gaze cueing task with directional social cues (eye gaze) and nonsocial cues (arrows) at varying stimulus onset asynchronies. As predicted, schizophrenia participants had reduced social attention relative to nonsocial attention, compared with healthy participants. Healthy participants were quicker to respond to social cues than nonsocial cues, but schizophrenia participants did not exhibit this same pattern. Schizophrenia participants showed higher accuracy when targets appeared in the same location as a directional cue (i.e., congruency) for nonsocial, but not social, cues. Contrary to expectations, reduced social attention was not significantly correlated with clinically rated social motivation deficits or decreased social functioning in the schizophrenia group. These findings provide evidence for social attention deficits in schizophrenia, but without a clear mapping of its influence on social motivation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

The aim of this study was to elucidate individual difference factors that modulate the attentional processing of game stimuli to explain the heterogeneity of extant findings. The current study examined whether individual differences in components of attentional control (AC-shifting and AC-focusing) moderated the link between internet gaming addiction symptom and attentional engagement to and disengagement biases from game-relevant cues. A total of 75 male undergraduate students who have played League of Legend (LOL) for more than 2 years completed well-established self-report questionnaires of internet gaming disorder symptoms and attentional control. The attentional bias toward game stimuli was measured for attentional engagement and disengagement using the attentional response to the distal vs. proximal emotional information (ARDPEI) task. The results revealed that attentional control was a significant moderator of the relationship between internet game addiction symptoms and attentional disengagement bias. Further analyses revealed a positive relationship between internet game addiction symptoms and attentional disengagement bias only among those with low levels of AC-shifting ability. Contrary to our expectations, AC-shifting also moderated the relationship between internet gaming disorder and attentional engagement bias. The positive relationship between internet game addiction symptoms and attentional engagement bias only appeared among those with low levels of AC-shifting ability. Individual differences in AC-focusing did not moderate the relationship between internet gaming disorder and any attentional bias. This study confirmed that the greater the symptoms of game addiction, the stronger the attentional bias, especially in individuals with low AC-shifting ability. Therefore, it is necessary to examine sub-factors of AC in understanding the nature of attentional bias mechanisms in the development of internet game addiction and consider it as a psychological intervention to improve attentional bias.

Sharing attention with interactive social partners, referred to as social attention, is fundamental to our efficient social interactions and adaptive functioning, since it enables us to learn about the other person's inner state and where the important events are in the environment. In recent years, researchers have systematically investigated the specific cognitive and neural mechanisms of social attention using a combination of psychophysical paradigms (e.g., adapted central cueing paradigm), neuroimaging techniques (e.g., ERP, MEG) as well as neuropsychological methods (e.g., brain-damaged patients). Some studies have demonstrated that social cues (e.g., eye gaze, head orientation and biological motion walking direction) can trigger reflexive attentional orienting effect, which is unique and qualitatively distinct from the attentional effect induced by nonsocial cues (e.g., arrow) in terms of both behavioral responses and neural activities. However, other studies have found that social and nonsocial attention share common neural substrates, and there is still controversy concerning the specificity of social attention. Combined with previous evidence, the major distinction between social and nonsocial attention is plausible that social attention might be mediated by an innate and genetically determined module, while nonsocial attention may occur as a result of long-teim experience (overlearning). Future research, exploring the genetic origins of social and nonsocial attention, may help to provide evidence for the existence of social attention detector and highlight the role of social attention in the early diagnosis and clinical intervention of autism.

A Computational Model for Cued Infant Learning

Previous research has shown that infants can learn from social cues. But is a social cue more effective at directing learning than a non-social cue? This study investigated whether 9-month-old infants (N = 55) could learn a visual statistical regularity in the presence of a distracting visual sequence when attention was directed by either a social cue (a person) or a non-social cue (a rectangle). The results show that both social and non-social cues can guide infants’ attention to a visual shape sequence (and away from a distracting sequence). The social cue more effectively directed attention than the non-social cue during the familiarization phase, but the social cue did not result in significantly stronger learning than the non-social cue. The findings suggest that domain general attention mechanisms allow for the comparable learning seen in both conditions.

My thesis studies how people pay attention to other people and the environment. How does the brain figure out what is important and what are the neural mechanisms underlying attention? What is special about salient social cues compared to salient non-social cues? In Chapter I, I review social cues that attract attention, with an emphasis on the neurobiology of these social cues. I also review neurological and psychiatric links: the relationship between saliency, the amygdala and autism. The first empirical chapter then begins by noting that people constantly move in the environment. In Chapter II, I study the spatial cues that attract attention during locomotion using a cued speeded discrimination task. I found that when the motion was expansive, attention was attracted towards the singular point of the optic flow (the focus of expansion, FOE) in a sustained fashion. The more ecologically valid the motion features became (e.g., temporal expansion of each object, spatial depth structure implied by distribution of the size of the objects), the stronger the attentional effects. However, compared to inanimate objects and cues, people preferentially attend to animals and faces, a process in which the amygdala is thought to play an important role. To directly compare social cues and non-social cues in the same experiment and investigate the neural structures processing social cues, in Chapter III, I employ a change detection task and test four rare patients with bilateral amygdala lesions. All four amygdala patients showed a normal pattern of reliably faster and more accurate detection of animate stimuli, suggesting that advantageous processing of social cues can be preserved even without the amygdala, a key structure of the “social brain”. People not only attend to faces, but also pay attention to others’ facial emotions and analyze faces in great detail. Humans have a dedicated system for processing faces and the amygdala has long been associated with a key role in recognizing facial emotions. In Chapter IV, I study the neural mechanisms of emotion perception and find that single neurons in the human amygdala are selective for subjective judgment of others’ emotions. Lastly, people typically pay special attention to faces and people, but people with autism spectrum disorders (ASD) might not. To further study social attention and explore possible deficits of social attention in autism, in Chapter V, I employ a visual search task and show that people with ASD have reduced attention, especially social attention, to target-congruent objects in the search array. This deficit cannot be explained by low-level visual properties of the stimuli and is independent of the amygdala, but it is dependent on task demands. Overall, through visual psychophysics with concurrent eye-tracking, my thesis found and analyzed socially salient cues and compared social vs. non-social cues and healthy vs. clinical populations. Neural mechanisms underlying social saliency were elucidated through electrophysiology and lesion studies. I finally propose further research questions based on the findings in my thesis and introduce my follow-up studies and preliminary results beyond the scope of this thesis in the very last section, Future Directions.

This study investigated whether modes of attentional selection (location-based or object-based) are modulated by the cue type, specifically social cues such as eye gaze and pointing fingers, or by a non-social cue, such as an arrow. Earlier studies have demonstrated that the object-based attention effect was found only with arrow cues when presenting a spatial cue at either end of a rectangle: gaze cues did not yield object-based facilitation. We examined whether this deficiency of object-based attention is generalized to social cues such as pointing fingers. We measured the reaction times to the target at each cued location, an opposite side of a cued location in the same object, or the location in a different object equidistant from the cued location for each cue. Results indicated that only the gaze cue weakened the object-based attention effect, even under the condition of participants' voluntary extension of their attentional focus. The pointing cue induced sufficient object-based facilitation, as did the arrow cue. These results suggest that the deficiency of object-based attention was observed only for the gaze cue, and that it would be caused by a factor that is unique to the gaze cue, which narrows the attentional focus.

Social attention is crucial for adaptive social behaviors and nonverbal communications in humans, and the malfunction of which has been implicated in autism, a highly genetic neurodevelopmental disorder marked by striking social deficits. The present study investigated the genetic contribution to individual variation in social attention. Using a classical twin design, the heritability of reflexive attentional orienting effects induced by two distinctly different social cues (i.e., eye gaze and biological motion walking direction) was examined. Results revealed reliable genetic influences on reflexive social attention of both cues, and further analyses of the effect concordance for twin pair members across the two types of cues yielded significant positive correspondence for MZ twins (with identical genes) but not for DZ twins (sharing 50% genes), indicating that common genetic factors may be involved in driving the attentional effects induced by these two different forms of social cues. Moreover, no evidence of heritability was observed when nonsocial cues (i.e., arrows) were employed in the control experiment. These findings together suggest the role of social attention in seeking the potential endophenotypes for autism and encourage the identification of "social attention genes". Meeting abstract presented at VSS 2013

Attentional biases in pediatric chronic pain: an eye-tracking study assessing the nature of the bias and its relation to attentional control.