Criterios diagnósticos en 400 biopsias de adenocarcinoma de próstata

Abstract

ObjectiveTo analyze a number of prostate biopsies evaluated by the same pathologist, to find the frequency of minimal histological criteria for prostate cancer and the new changes in the consensus of urologists in the Gleason classification. Materials and MethodsA total of 400 ultrasound-guided biopsies performed using a number 18 needle, and with the hematoxylin-eosin stained sections being evaluated by the same pathologist. ResultsThe histological characteristics in neoplastic glands were stromal infiltration (100%), no basal layer (100%), prominent nucleoli (98%), multiple nucleoli (60%), intraluminal crystalloids (40%), intraluminal amorphous eosinophilic material (70%), collagen micro nodules (1%), glomeruloid structures (10%), perineural invasion (20%), stromal retraction (32%) and invasion of fat (1%). Other associated histological findings were observed, such as atrophy, basal cell hyperplasia, atypical small acinar proliferation. Finally, was the assessment of the Gleason grading was assessed according to the new consensus of urologists seeing an increase in the number of cases with Gleason 7. ConclusionsThe histological diagnosis of prostate cancer based on this study show that the most common criteria are stromal infiltration, absence of basement membrane and prominent nucleoli. Pathologists should be aware, and become familiar with this classification, as well as the changes that have been made over time.© 2012 Sociedad Colombiana de Urología. Published by Elsevier España, S.L. All rights reserved.