Abstract
Relevance . The work is devoted to the study of the therapeutic efficacy of the drug Enroflon® gel on cows of the Holstein-Friesian breed, as well as the Holsteinized black-and-white breed during lactation. The aim of the research was to determine the therapeutic efficacy of Enroflon ® gel in the treatment of subclinical and clinical mastitis of bacterial etiology, as well as determination of the residual presence of antibiotics in milk samples from animals subjected to treatment. Methodology. Production experience to determine the therapeutic effectiveness of clinical (experience 1) and subclinical (experience 2) mastitis was carried out in the conditions of the farm of LLC “Babaevo” of Vladimir region. Two experimental groups of cows with clinical and subclinical mastitis were formed. An industrial experiment to determine the residual amount of enrofloxacin in milk (experiment 3) was carried out in the conditions of the livestock complex of LLC “Lesnye Polyany», Moscow region. An experimental group (experiment 3) of cows with subclinical mastitis was formed. The diagnosis of subclinical mastitis was made on the basis of a diagnostic test for the determination of somatic cells using the Kenotest system. The presence of a residual amount of antibiotic was determined in the Research Laboratory “Milk” of the Federal State Scientific Institution “All-Russian Research Institute of the Dairy Industry”. The complex preparation Enroflon ® gel was injected intracisternally into the inflamed lobe of the udder with clinical and subclinical mastitis during lactation. The drug was administered 2 times a day with an interval of 12 hours for 3 days. The investigated drug was produced at LLC “VIC Animal Health”. Results . In the treatment of clinical (experiment 1) and subclinical (experiment 2) mastitis in cows using Enroflon ® gel the therapeutic effect was 80% and 100% respectively. In laboratory studies of milk samples using the RANDOX matrix biochip technology (experiment 3) no active ingredient, enrofloxacin, was detected in all treated animals 72 hours after the last injection of the drug.
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