Abstract
Many preterm infants, particularly those with birth weight ≥1.0 kg, are given multiple red blood cell (RBC) transfusions during the early weeks of life. Many controversial questions regarding the practice of neonatal RBC transfusion therapy exist, so that practices and policies vary widely — including the clinical indications and physiological basis for RBC transfusions, the choice of RBC product to be transfused, and the need for RBC product modifications such as leukocyte-reduction and gamma-irradiation. This manuscript will critically assess information pertaining to one of these issues — namely, the selection of RBCs stored for up to 42 days after collection in extended-storage preservative solutions for transfusing infants vs the transfusion of fresh RBCs (ie, those stored ≥7 days after donation).
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