Abstract
BackgroundSeveral studies have reported the Cyclooxygenase 2 (COX-2) rs689466 polymorphism as a susceptibility locus of colorectal cancer (CRC), but their findings are inconsistent. Thus, this meta-analysis was performed to more accurately identify the effects of this polymorphism on CRC risk.MethodsPotential case-control studies on EMBASE, Google Scholar, Web of Science, Cochrane Library, and PubMed were searched. The strength of association was quantified by pooled odds ratio and 95% confidence interval. Totally 16 articles involving 8998 cases and 11,917 controls were included.ResultsNone of the five tested genetic models revealed an association between rs689466 polymorphism and CRC risk. Stratified analysis by ethnicity uncovered a positive association between this polymorphism and higher CRC risk in Caucasians, but not in Asians. In addition, we found that high expression of COX-2 was associated with better overall survival for all CRC patients.ConclusionTo sum up, the COX-2 rs689466 polymorphism may be related with susceptibility to CRC in Caucasians. This finding should be verified by larger-size studies with different ethnic groups.
Highlights
Colorectal cancer (CRC), the second largest cause of cancer-induced death in the world [1], was estimated to cause 135,430 new cases and 50,260 deaths in the USA in 2017 [2]
Two studies failed to conform to Hardy–Weinberg equilibrium (HWE) [15, 22]
The Newcastle-Ottawa Scale (NOS) scores range from 5 to 7 stars, suggesting that the included studies are all of high quality
Summary
Colorectal cancer (CRC), the second largest cause of cancer-induced death in the world [1], was estimated to cause 135,430 new cases and 50,260 deaths in the USA in 2017 [2]. The association between rs689466 polymorphism and CRC risk has been explored extensively [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25]. Several studies have reported the Cyclooxygenase 2 (COX-2) rs689466 polymorphism as a susceptibility locus of colorectal cancer (CRC), but their findings are inconsistent. This meta-analysis was performed to more accurately identify the effects of this polymorphism on CRC risk
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