Abstract
World facing pandemic challenges of SARS-Co-2 (Severe Acute Respiratory Syndrome Corona Virus 2). Tyrrell and Bynoe identified first strain of human corona virus in 1965. Infection was originated from Wuhan city of China on November 2019. Virus officially named as COVID-19 which causes respiratory tract infections in humans. Preliminary symptoms like chest pain with difficulty in breathing, reduced in systemic oxygen level, cough and fever. At present, the majority of the pharmaceutical companies were in race to developing antiviral drug and vaccines against COVID-19. Industries conducting the experiment and clinical trial of various vaccines to ensure effectiveness and safety on human. Several of them were documentation for patent, authorization of clinical trial and marketing. We provide an overview of Covid-19 history, types of vaccine and mechanism of actions, current future therapeutic drugs and patents. Relative with the mechanism of actions such as inactivated vaccine, vector vaccines, DNA and RNA based vaccine and antiviral drugs already entered in (Phase II and III) clinical trials. The systemic study specified brief summary of various vaccines. Current status of clinical trial, safety and effectiveness according to ICH guidelines. A major adverse interaction with their toxicity study. The information of approved which give opportunity for upcoming scientist to improve the quality, and minimize the adverse effects. Scientist may face challenges during the post marketing clinical trial. This pandemic has provided various scopes for researchers to develop vaccine and antiviral drugs.
Highlights
Corona virus caused an infectious disease by severe acute respiratory syndrome (SARS-COV-2)
Pfizer BioNTech has, like Moderna, spread a vaccine that uses mRNA to bring about the immune system to identify the corona virus
There is no risk of getting Covid 19 from a vaccine, as the virus is never present in the body [12]
Summary
Corona virus caused an infectious disease by severe acute respiratory syndrome (SARS-COV-2). Covid-19 first case was being identified in Wuhan, China, in November 2019 [2, 3]. In human they cause respiratory tract infections. Main Symptoms identify human corona virus is Common Cold [6]. Researcher said that, it's a big Familiar disease and again Common cold main symptoms present infected patient [5]. Identify Corona virus officially name as SARS-CoV-2 (Severe acute respiratory syndrome) by International Committee on Taxonomy of Virus researcher said novel corona virus originated in bats [5]. Spanish Flu (H1N1) (Influenza A Virus) [9] Asian Flu (H2N2) (Influenza A virus) [9] Hong Kong Flu (H3N3) (Influenza A Virus) [7] Zaire Ebola virus (EBOV) Pandemic Flu (H1N1) (Influenza A Virus)[10] Covid-19 (SARS-COV-2) Corona virus
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