Abstract
On May 28, 1982, the Food and Drug Administration issued a letter to physicians and hospital pharmacists concerning the apparent toxicity of benzyl alcohol in premature infants (H. M. Meyer, Jr, Director, Bureau of Drugs and Biologics, Public Health Service, Food and Drug Administration, Rockville, MD). Cases were described in which neonates weighing less than 2,500 gm had died from a syndrome consisting of metabolic acidosis, CNS depression, respiratory distress, hypotension, renal failure, and sometimes seizures and intracranial hemorrhages.
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