Abstract

Like a music box , in nanopore single-molecule frequency fingerprinting a rotating metal cylinder (an analyte) uses perfectly placed pins (the chemical groups of an analyte) that come up under the comb (the characteristic residue inside the nanopore inner wall) to strike the appropriate prongs or tines of that comb (confined interactions). In this way, each analyte generates a characteristic fingerprint frequency as it undergoes the confined interactions with the nanopore, as explained by Yi-Lun Ying, Yi-Tao Long et al. in their Research Article on page 24582.

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