Abstract
A pH-responsive drug delivery system based on mesoporous silica nanoparticles (MSN) has been prepared for the delivery of three drugs with different modes of action (phthalocyanine (Pc) camptothecin (CPT) and doxorubicin (DOX)). The pores of the MSN were loaded with a photoactive conjugate formed from Pc and CPT joined by a glutathione-sensitive linker. DOX was covalently bound to the outer surface of the MSN through a dihydrazone poly(ethylene glycol) linker. Uptake studies demonstrated proper endocytosis of the system and subsequent delivery of the three drugs into the cytoplasm and nucleus. The synergistic effect of the drugs and Pc upon light irradiation was also assessed in vitro. More information can be found in the Full Paper by T. Torres, D. K. P. Ng, D. Sánchez-García et al. (DOI: 10.1002/chem.202101842).
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