Abstract
Under catalyst-free conditions, decarboxylative fluorination of lithium 2-pyridylacetates easily occurs. An electrophilic fluorinating reagent dramatically accelerates the decarboxylation of lithium 2-pyridylacetates; this phenomenom has led to a one-pot transformation of methyl 2-pyridylacetates to 2-(fluoroalkyl)pyridines via intermediate lithium 2-pyridylacetates. The method has also been applied to the syntheses of 2-(difluoroalkyl)pyridines. More information can be found in the Communication by K. Shibatomi, et al. on page 7453.
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