Abstract
Enantioselective gold redox catalysis was achieved with newly designed chiral hemilabile P,N ligands (shown as a heavy load in the truck). We reveal a new strategy through a two-step sequence: A) Apply a chiral hemilabile P,N ligand at the AuI stage to promote AuI oxidative addition toward aryl iodide; B) nucleophilic addition to a chiral AuIII intermediate formed in situ as a stereodetermining step (SDS). This strategy presents a new opportunity to enrich the versatile reactivity of gold catalysis in an enantioselective fashion. More information can be found in the Research Article by M. Li, X. Shi and co-workers (DOI: 10.1002/chem.202201018).
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