Abstract
We have explored morphology of DNA molecules bound with Cu complexes of piroxicam (a non-steroidal anti-inflammatory drug) molecules under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.
Highlights
Condensed state behaviour of DNA, the best-known biopolymer, in a confined space is a matter of interest due to its relevance in living systems
We have studied effect of counterions on the confined state of metal–drug–DNA complexes, because within living systems such complexes exist in the presence of various salt ions, in a highly confined state
We have studied thin films comprising of composites of DNA and a Cu(II) complex of piroxicam in presence and absence of buffer molecules
Summary
Condensed state behaviour of DNA, the best-known biopolymer, in a confined space is a matter of interest due to its relevance in living systems. Regarding confinement effects at the nanometer scale, we have observed that in absence of counterions DNA molecules Form layered structures aligned laterally to the film surface, whereas in case of films prepared from buffered solution there is no such layering due to the increased orientational entropy of entangled shorter DNA molecules [8,9].
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