Counteraction of amyloid-β aggregation by vitamin A and E metabolites in a crowded environment

Abstract

Alzheimer’s disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether these molecules participate in protein homeostasis by modulating Aβ aggregation. By screening 18 fat-soluble and water-soluble vitamins, we found that retinoic acid and alpha-tocopherol, two metabolites of vitamin A and vitamin E, respectively, affect Aβ42 aggregation both in vitro and in a C.