Abstract
Different Keggin‐type heteropolycompounds were used in Pechmann reaction to obtain biologically active coumarins. Effect of solvent, catalyst loading, and molar ratios of substrates was studied to introduce the best reaction condition. The optimized reaction condition was extended to Pechmann reaction of methylacetoacetate with various monohydric and polyhydric phenols. This rapid procedure afforded structurally diverse coumarins with high to excellent yields. Short reaction times, simple work‐up, and mild reaction conditions were advantages of this method. The optimized catalysts were reusable for four runs.
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