Abstract
Corynebacterium bovis Eye Infections, Washington, USA, 2013.
Highlights
In 2 studies that evaluated the effect of adjunctive IL-2 therapy in addition to ART for previously treatment-naive patients with HIV infection, baseline median numbers of circulating CD4+ cells increased significantly, but expansion of CD4+ T cells was not associated with the reduction in the risk for opportunistic diseases or death [8]
In the absence of inflammatory responses to pathogens, the patient is unprotected, and even microbiota that are harmless to an immunocompetent person can adversely invade
9 cases of C. bovis infections in humans have been reported [3,4,5,6], only the most recent case, which involved prosthetic joint infection, used 16S rRNA gene sequencing to identify the bacterium with certainty [6]
Summary
In 2 studies that evaluated the effect of adjunctive IL-2 therapy in addition to ART for previously treatment-naive patients with HIV infection, baseline median numbers of circulating CD4+ cells increased significantly, but expansion of CD4+ T cells was not associated with the reduction in the risk for opportunistic diseases or death [8]. Corynebacterium bovis Eye Infections, Washington, USA, 2013 J.E. Clarridge); Veterans Administration Puget Sound Health Care System, Seattle C. bovis infections in humans are rare, and identification of the organism by biochemical methods is challenging [2].
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