Abstract
Beta-adrenergic blocking agents have a significant corticosteroid-sparing effect in the treatment of pemphigus vulgaris. In 18 patients, observations over a period of 8-27 months have shown that, in terms of percentage of the maintenance dose of betamethasone when administered alone, the corticosteroid-sparing effect of propranolol 120 mg was 33.3–83.3% in 17 patients and 100% in 1 patient. It is postulated that propranolol affects the vasodilator fibres as a result of which the influx of plasma in blisterformation is prevented or minimised.
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