Corrigendum

Abstract

Journal of Veterinary Pharmacology and TherapeuticsVolume 33, Issue 6 p. 622-622 Free Access Corrigendum This article corrects the following: Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity R. A. HUANG, L. T. LETENDRE, N. BANAV, J. FISCHER, B. SOMERVILLE, Volume 33Issue 3Journal of Veterinary Pharmacology and Therapeutics pages: 227-237 First Published online: September 1, 2009 First published: 09 November 2010 https://doi.org/10.1111/j.1365-2885.2010.01245.xCitations: 1AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In (Huang et al., 2010) the following errors were published on page 231 and 233. On page 231, the original read: The 95% confidence limits on the parameters were determined at a 95% level of certainty. This is incorrect and should read: The 90% confidence limits on the slope parameter were determined. On page 233, the original read: The coefficient of determination was 0.9214 and both parameters were highly statistically significant (P < 0.0001). The confidence interval on the slope encompassed 1.00 (0.75342, 1.14376). The confidence interval for the intercept (7.08078, 7.68696) does not include zero, suggesting that the AUC does not increase proportionally with dose over the entire range of doses from 0 to 9 mg/kg. Dose linearity of the AUCinf (Fig. 4) was therefore established over the range of 0.5–1.5 times the recommended dosage rate of 6 mg/kg of body weight. This is incorrect and should read: The coefficient of determination was 0.9214 and the slope was highly statistically significant (P < 0.0001). The 90% confidence interval (CI) on the slope encompassed 1.00 (0.79, 1.11) and is very close to being within but does not strictly meet the CI critical region of 0.80–1.25 that would confirm a proportionate increase in exposure using the bioequivalence confidence interval criteria (Smith et al., 2000; Hummel et al., 2009). Small deviations from dose proportionality over a 3-fold dose range, not detectable with this study design, would not be therapeutically important. Increases in the gamithromycin dose are therefore expected to result in proportional increases in plasma concentrations over the range of 3–9 mg/kg that were tested in this study. The authors apologize for these errors and would like to thank Dr Marilyn Martinez and Professor P.L. Toutain for their discussions of this topic. References Huang, R.A., Letendre, L.T., Banav, N., Fischer, J. & Somerville, B. (2010) Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. Journal of Veterinary Pharmacology and Therapeutics, 33, 227– 237. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Hummel, J., McKendrick, S., Brindley, C. & French, R. (2009) Exploratory assessment of dose proportionality: review of current approaches and proposal for a practical criterion. Pharmaceutical Statistics, 8, 38– 49. Wiley Online LibraryPubMedWeb of Science®Google Scholar Smith, B.P., Vandenhende, F.R., DeSante, K.A., Farid, N.A., Welch, P.A., Callaghan, J.T. & Forgue, S.T. (2000) Confidence interval criteria for assessment of dose proportionality. Pharmaceutical Research, 17, 1278– 1283. CrossrefCASPubMedWeb of Science®Google Scholar Citing Literature Volume33, Issue6December 2010Pages 622-622 ReferencesRelatedInformation