Correlation study of Myocardial strain imaging with angiographic findings in patients with chronic stable angina

Abstract

Background: Global Longitudinal Strain (GLS) measured by 2D speckle-tracking strain echocardiography (2D-STE) can detect impaired longitudinal left ventricle (LV) function at rest which is associated with significant coronary artery stenosis. Objective: Global longitudinal strain (GLS) may be used to predict the presence, extent and severity of CAD according to coronary angiographic findings in patients with chronic stable angina. Methods: 2D-STE and coronary angiography were performed on 100 individuals with suspected stable angina pectoris who had normal resting conventional echocardiography. Global longitudinal strain were assessed and were correlated with coronary angiography for each patient. Results: Statistically significant difference was found when comparing the mean GLS among patients with normal coronaries and different degrees of coronary artery disease (CAD).Mean GLS was – 20.76±1.39, -17.66±0.65, - 16.05±0.58 and -14.22±0.65 for normal/minor, single vessel, two vessels and three vessels respectively(p<0.001). Patients with significant left main (LM) stenosis had GLS of 14.41±1.27 compared with GLS of 17.1±1.91in patients without LM stenosis (p=<0.001). In our study cutoff value for detection of single vessel disease was -18.300 with good sensitivity and specificity (100% and 96.6%, respectively) with AUC (Area Under the Curve) 0.996 and p value< 0.001.