Correlation of Systemic Inflammatory Index and Neutrophil Platelet Ratio with Intracranial Haemorrhage and Mortality After Endovascular Treatment Due to Acute Ischaemic Stroke

Abstract

Many studies in recent years have shown that systemic and local inflammatory responses following various diseases are important markers of tissue damage. We aimed to investigate the correlation of systemic inflamatory index and neutrophil platelet ratio with intracranial haemorrhage and mortality in patients undergoing endovascular treatment due to ischaemic stroke. Between 2022 and 2024, patients who hospitalised in the Antalya Training and Research Hospital Neurology intensive care unit after endovascular treatment were screened. Patients over 18 years of age with a door-needle time of less than 24 hours and who underwent endovascular treatment for successful internal carotid artery ICA, MCA, and basilar artery occlusion due to acute ischaemic stroke were included in the study. A total of 133 patients were included. intracranial haemorrhage was observed in 59 (44.4%) patients, and exitus developed in 38 (28.6%) patients. There was a correlation between the development of intracranial haemorrhage and systemic inflamatory index and neutrophil platelet ratio. A statistically significant difference was observed between the neutrophil platelet ratio and systemic inflamatory index median values according to mortality status, and neutrophil platelet ratio values were higher in patients who developed exitus. In conclusion, our findings indicate the correlation of systemic inflamatory index and neutrophil platelet ratio independently with intracranial haemorrhage and mortality in patients with endovascular treatment. These noninvasive and cost-effective inflammatory markers may constitute a good biomarker for intracranial haemorrhage and mortality after endovascular treatment. In order to confirm these findings, prospective studies with a larger population of patients are needed.