Abstract
ObjectiveWe investigated the correlation between serum anti-Toxplasma gondii IgG and suicidal thoughts in depressive patients.MethodsDepressive patients with (n = 100) and without (n = 100) suicidal thoughts along with 100 healthy control subjects were recruited for this study. In all three groups, a semi-structured clinical interview form called Structured Clinical Interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) Axis-I Disorder (SCID-I), Hamilton Depression Rating Scale (HAMD), suicidal behavior scale, and a sociodemographic data form were completed. Sera from all participants were taken, and anti-toxoplasma IgG was measured by Enzyme Linked Immunosorbent Assay (ELISA)-Chemiluminescent Microparticle Immunoassay. Statistical analysis of the data was performed.ResultsThe serum anti-toxoplasma IgG levels of patients with suicidal thoughts were significantly higher than those without suicidal thoughts and the controls, which were 80.04 ± 40.66, 78 ± 14.82, and 19.98 ± 14.65, respectively, p < 0.001. There was no correlation between toxoplasma IgG and HAMD score in patients lacking suicidal thoughts (r = -0.112, p = 0.463).ConclusionThis study shows a correlation between seropositivity for anti-Toxoplasma gondii IgG and depression with suicidal thoughts.
Highlights
Toxoplasmosis and depression are close concepts in their stages in modern, isolated human life
This study shows a correlation between seropositivity for anti-Toxoplasma gondii IgG and depression with suicidal thoughts
In a report prepared by the World Health Organization (WHO) on World Mental Day (October 10, 2012), whose main theme was "Depression as a Global Crisis," depression accounted for 4.3% of the global illness burden and was the third leading cause of illness [1]
Summary
Toxoplasmosis and depression are close concepts in their stages in modern, isolated human life. Feline contact by humans is on the increase. In a report prepared by the World Health Organization (WHO) on World Mental Day (October 10, 2012), whose main theme was "Depression as a Global Crisis," depression accounted for 4.3% of the global illness burden and was the third leading cause of illness [1]. It has been reported that 20% of the emerging diseases due to psychiatric disorders in Europe are resulted from depression, and in some countries this rises up to 26%. Depression is an important public health problem that causes 3000 deaths per day as a result of suicide. Longitudinal follow-up studies show that 10%-15% of suicide attempts have been successful [1,2]
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