Abstract
BackgroundPregnancy-associated plasma protein A (PAPP-A) is abundantly expressed in carotid plaques. This study investigated the association between single nucleotide polymorphisms (SNPs) of PAPP-A and the presence of carotid plaques.MethodsA total of 408 patients with carotid plaques and 493 controls were included in the study. All subjects were Southern Chinese Han. Carotid plaques were analyzed by computer tomography angiography. PAPP-A SNPs were identified by ligase detection reaction-polymerase chain reaction analysis. The PAPP-A genotypes rs3747823, rs7020782, and rs13290387 were analyzed.ResultsThe rs7020782 C allele genotype correlated with an increased risk of developing carotid plaques under the dominant, recessive, and additive models (adjusted odds ratios: 2.60, 2.36, and 3.48, respectively; P ≤ 0.001). Only C allele-carrying genotypes correlated with a significantly increased risk of carotid plaque based on studies stratified by age and sex under the dominant model. rs7020782 remained significantly associated with the risk of carotid plaque calcification after adjusting for age and potential confounders (adjusted odds ratio, 1.89; 95 % confidence interval, 1.17–3.08; P = 0.010).ConclusionsThis study found, for the first time, that the A˃C variation of rs7020782 might be an independent risk factor for carotid plaque development and calcification. The determination of such genotypes could provide a new tool for identifying individuals at high risk for carotid atherosclerosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-015-0041-1) contains supplementary material, which is available to authorized users.
Highlights
Pregnancy-associated plasma protein A (PAPP-A) is abundantly expressed in carotid plaques
There were no significant differences in Fasting plasma glucose (FPG), total plasma cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C), Body mass index (BMI), or smoking between the two groups
The present study investigated whether PAPP-A polymorphisms contributed to susceptibility to carotid plaques in a Southern Chinese Han population containing 408 patients and 493 controls
Summary
Pregnancy-associated plasma protein A (PAPP-A) is abundantly expressed in carotid plaques. This study investigated the association between single nucleotide polymorphisms (SNPs) of PAPP-A and the presence of carotid plaques. Pregnancy-associated plasma protein A (PAPP-A) is a metalloproteinase that regulates insulin-like growth factor (IGF) and acts as a biomarker of inflammation [1,2,3,4]. It is abundantly expressed in carotid plaques, which form an important pathological basis of strokes. PAPP-A expression has been linked with carotid vulnerable plaque development, and serum PAPP-A levels with carotid atherosclerosis. The association between PAPP-A and carotid plaques deserves further research [13, 16]
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