Abstract
Objective To investigate the correlation of serum visfatin level with insulin resistance and fetal development in patients with preeclampsia-eclampsia. Methods 48 patients with preeclampsia-eclampsia were collected; among which, 22 cases had mild preeclampsia, 18 severe preeclampsia, and 8 eclampsia. In addition, 30 cases of normal late pregnant women in the same period were selected as a control group. The levels of serum visfatin, fasting blood glucose, insulin, and HOMA-IR in all the groups were measured. At the same time, the perinatal birth weight, body length, and placental weight of all the groups were compared. The relationships between the perinatal birth weight, body length, placental weight, serum visfatin, fasting blood glucose, insulin, and HOMA-IR were analyzed. Results The levels of blood glucose, blood insulin, HOMA-IR, and visfatin were significantly higher in the severe group and the eclampsia group than in the control group and the mild group (all P<0.05). The levels of blood glucose, blood insulin, HOMA-IR, and visfatin were significantly higher in the eclampsia group than in the severe group (all P<0.05). The birth weight and placental weight were significantly lower in the severe group and in the eclampsia group than in the control group and in the mild group (all P<0.05). The birth weight and placental weight were significantly lower in the eclampsia group than in the severe group (both P<0.05).There was a positive correlation between serum visfatin and blood glucose and between insulin and HOMA-IR in the severe group; and there was a negative correlation between birth weight and placenta weight, especially HOMA-IR. The serum visfatin in the eclampsia group positively correlated with blood glucose, insulin, and HOMA-IR and negatively with birth weight and placental weight. Conclusions IR and blood visfatin in patients with preeclampsia and eclampsia are elevated; and there is a close correlation between them. Meanwhile, the level of serum visfatin has a significant effect on the growth and development of fetus. Key words: Preeclampsia; Eclampsia; Alfatin; Insulin resistance; Fetal development
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