Correlation of Serum Uric Acid Level to Perinatal Outcome in Preeclamptic Women

Abstract

Background: Hypertensive disorders are common in pregnancy. Several studies showed a positive correlation between elevated maternal serum creatinine and adverse maternal and fetal outcomes in pre eclamptic women, but only a few studies are available on serum creatinine and maternal and fetal outcomes. The present study was under taken to study the association of maternal serum uric acid with fetal outcomes in pre eclamptic women. Aim and objective: To Study correlation of serum uric acid level to perinatal outcome in preeclamptic women: Material and Methods : The Study was performed on two groups of women with hypertensive disorders of pregnancy; the first group (n=50) with a serum uric acid level of ≥6mg/dl was compared to the second group (n=50) with a serum uric acid level of <6mg/dl. Perinatal complications like IUFD (Intra-Uterine Fetal Death), low APGAR score, IUGR (Intra-Uterine Growth Retardation) NICU admissions, prematurity and perinatal death were studied. Results: In the present study perinatal outcome was studied among 100 pre eclamptic women. In group A, there were 22 pre-term babies , 20 IUGR and 41 babies had low APGAR (<7) In group B, 9 preterm babies, 12 IUGR, 28 babies with low APGAR (< 7). So these entire abnormal fetal outcomes were higher in Group A (uric acid ≥6mg/dl) .In group A, there were 29 babies required NICU admission, 11 perinatal deaths. In group B, 17 babies required NICU admission and 5 perinatal deaths. Conclusion: Maternal serum uric acid concentration is a good predictor of foetal outcome in women with preeclampsia/ eclampsia. Key words: Uric acid, Creatinine, Pre eclampsia, Gestational age , Birth weight