Abstract
We tested the hypothesis that, in elderly survivors of ischemic stroke, high NT-proBNP levels are related with frequent diastolic dysfunction. We prospectively measured NT-proBNP, left ventricular ejection fraction (LVEF) and echographic parameters of diastolic function in 55 elderly consecutive patients, 6.8 ± 2.6 days after acute ischemic stroke. We found that all the patients had systolic or diastolic dysfunction (14 had LVEF < 50%, 26 mild diastolic dysfunction + LVEF ≥ 50%, and 15 moderate or severe diastolic dysfunction + LVEF ≥ 50%). The most powerful predictors of NT-proBNP were LVEF ( R = 0.38, p = 0.004) and ratio of mitral E to the early diastolic velocity of the mitral annulus: E/ E'( R = 0.34, p = 0.01).
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