Abstract
Abstract In previous work the composition of surfactant isolated from cell-free bronchoalveolar lavage (CF-BAL) from the right lungs of monkeys instilled with 500 mg of either generic bituminous, anthracite, quartz, or titanium dioxide dust was compared with that of surfactant isolated from CF-BAL from control left lungs. Exposure to quartz, anthracite, or titanium dioxide induced a significant increase in the amount of protein recovered, which was evident throughout most of the time period (1 year) studied. Exposure to quartz also induced a significant decrease in the total amount of lipid-associated phosphorus. To determine whether dust-induced changes in surfactant composition paralleled changes in lung morphology, consecutive studies were carried out in rats. Rats were instilled with 50 mg of either quartz or anthracite dust/kilogram body weight. One milligram of bituminous dust was instilled with every 5 mg of quartz dust as a marker to indicate dust location. Histologic evaluation of quartz dust-exp...
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