Abstract
Type II Diabetes mellitus (TII DM) is a major global health problem. TII DM is characterized by the prothrombotic state of platelets which owes to the persistent hyperglycemia and insulin resistance, causing injury to pericytes and endothelium. Increased platelet activity is believed to be associated with the development of vascular complications in TII DM. Mean Platelet Volume (MPV), a marker of platelet function which can be used to assess the vascular complications. This is an observational study including 150 TII DM patients attending Diabetology OPD in Coimbatore Medical College& Hospital. MPV, FBS, PPBS, HBA1c were signicantly elevated in TII DM patients. Mean FBS, PPBS, HBA1c, MPV were 188.84±91.50mg/dL, 281.10±104.51mg/dL,8.56±2.25 %,9.66 ± 2.02fL, respectively. MPV showed a signicant positive correlation with FBS, PPBS, HBA1c. MPV showed more strong correlation in patients with HBA1c >7% than in patients with HBA1c ≤7%. Our study showed that in Type II Diabetes Mellitus patients, Mean Platelet Volume (MPV) is increased. MPV is signicantly increased in patients with high HBA1c level. Thus, MPV can be taken as a simple and a cost-effective parameter in assessing the Glycemic control in TII DM patients.
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