Abstract
Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care.Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico.Materials and methods: Cross-sectional study. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of 112 children (5-19 years old). Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR.Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198).Conclusions: In the study population, HOMA-IR has a moderately significant correlation with an increase in BMI percentile.
Highlights
Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases
(1) IR has been described as a major risk factor for type 2 diabetes mellitus and cardiovascular disease, conditions that have high morbidity and mortality rates, which explains its diagnostic importance. [2]
The state of Chiapas has a total population of 5 217 908 inhabitants, of whom 74.7% live in poverty and 33.5% lack access to health services. [14,15] Regarding overweight and obesity, a combined prevalence in adolescents from urban areas of the state of 33% has been reported [16], with a Homeostatic Model Assessment Insulin Resistance (HOMA-IR) range for the capital between 0.4-7.5 and 21% in obese adolescents
Summary
Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. [1] IR has been described as a major risk factor for type 2 diabetes mellitus and cardiovascular disease, conditions that have high morbidity and mortality rates, which explains its diagnostic importance. The use of HOMA-IR in routine clinical diagnosis has allowed observing that reference values range from 2.6 to 3.8 in adult and pediatric populations in different regions of the world [6,7,8,9]; determining reference values for specific populations is highly suggested. The state of Chiapas has a total population of 5 217 908 inhabitants, of whom 74.7% live in poverty and 33.5% lack access to health services. [14,15] Regarding overweight and obesity, a combined prevalence in adolescents from urban areas of the state of 33% has been reported [16], with a HOMA-IR range for the capital between 0.4-7.5 and 21% in obese adolescents. [17] These is relevant when taking into account that more than 80% of deaths from noncommunicable diseases such as type 2 diabetes occur in low- and middle-income countries such as Mexico. [18]
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