Abstract
Lymphocytes of donors and recipients were HL-A typed for 20 specificities in thirty cases of cardiac transplantation. ABO blood-group compatibility and a negative lymphocyte crossmatch were present in all cases. Standard postoperative immunosuppression including azathioprine, prednisone, and antilymphocyte or antithymocyte globulin was used. The number of HL-A incompatibilities ranged from one to four. There was no significant relationship between number of mismatches and postoperative survival, rejection history, or clinical status. The most striking finding was that HL-A mismatching does not preclude long-term survival with satisfactory graft function. Three of four recipients living more than 2 years after transplantation were mismatched for four antigens.
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