Abstract
Objective To investigate the correlation of human glandular kallikrein (hK)2 gene expression value with Gleason histologic grading and its clinical significance in prostate cancer. Methods hK2 gene expression of the cancer tissue was measured in 40 cases of prostate cancer. The Gleason histologic grading was based on histopathologic examination. Results The prostatic cancer hK2 gene expression values variated in different Gleason score. The hK2 gene expression values increased with the enhancement of Gleason scores. Conclusions The hK2 expression value is positively correlated with Gleason scores. The hK2 expression value may be an important indicator of the diagnosis, degree of malignancy and prognosis in prostate cancer. Key words: Prostatic neoplasms; Human glandular kallikrein 2; Gleason score; Diagnosis
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