Abstract
The interrelationships of ultrastructural and biochemical parameters have been studied in a multivariate analysis of 139 cases of invasive breast carcinoma. There was no relationship between the histologic subclassification and distribution of estrogen and progesterone receptors. However, significant correlations could be found between receptor status and certain ultrastructural features of the tumor cells. A prevalence of well differentiated cancers had a significant correlation with a positive estrogen receptor status. Estrogen receptors were more frequently associated to tumors showing great complexity of cytoplasmic organization, high degrees of cell interconnections by desmosomes and membrane interdigitations, presence of intracytoplasmic ductules, specific secretory granules, and low grades of nuclear pleomorphy.
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