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Abstract
Objective:To explore the correlation of dual-source computed tomography (DSCT)/dual-energy imaging with pathological grading of lung adenocarcinoma.Methods:A total of 47 patients with lung adenocarcinoma were selected. Tissues were histopathologically confirmed by routine DSCT scanning and dual-energy enhanced scanning. Arterial-phase and venous-phase iodine distribution images and single-energy images at 40-190 keV were obtained. The region of interest was outlined to obtain CT values. The iodine concentrations of each tumor in two phases were recorded to calculate normalized iodine concentrations (NICs).Results:The maximum diameter and minimum diameter of tumors in low differentiation (LD) group were significantly higher than those of high differentiation (HD) group (P<0.05). In LD group, 70.8% of margins were lobulated, which significantly exceeded that of HD group (30.4%) (P<0.05). Besides, 26.1% of patients in HD group were complicated with ground-glass opacity, which was significantly higher than that of LD group (4.2%) (P<0.05). In venous phase, there were significant differences between the two groups at low energy levels (40-70 keV) (P<0.05). At high energy levels (80-190 keV), the CT values of LD group were slightly higher than those of HD group. In arterial and venous phases, NICs of HD group were lower than those of LD group (P>0.05).Conclusion:HD and LD groups could be predictably distinguished by single-energy images at low energy levels (40-70 keV) in the venous phase. Quantitative analysis of NIC in the venous phase is also valuable for predicting the pathological grade of lung adenocarcinoma.
Highlights
Maximum and minimum tumor diameters: The maximum diameter and minimum diameter of tumors in the low differentiation (LD) group ((4.6±0.35) and (3.8±0.29) cm) were significantly higher than those of the high differentiation (HD) group ((3.3±0.26) and (2.7±0.27) cm) (P
Tumor margins: In the LD group, 70.8% of the margins were lobulated, which significantly exceeded that of the HD group (30.4%) (P
Complication with ground-glass opacity: In the HD group, 26.1% of patients were complicated with ground-glass opacity, which was significantly higher than that of the LD group (4.2%) (P
Summary
Xiao Li, 1,2: Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, People’s Republic of China. Correspondence: June 12, 2017 October 17, 2017. Lung cancer, which is one of the most common malignant tumors, has attracted wide attention recently due to high incidence and mortality rates.[1] Of all lung cancers, lung adenocarcinoma is most common, accounting for 44.5%-46.5%. The incidence rate of lung adenocarcinoma has been rising annually.[2] The degree of malignancy of lung adenocarcinoma can be determined by many factors among which pathological grade is an independent index. If the pathological grade of lung adenocarcinoma can be known before surgery in a noninvasive way, it is of great significance to determine the prognosis and to select appropriate treatment methods
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