Abstract
This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC). Nine relevant studies of 1,960 patients were identified using electronic database searches supplemented with a manual search in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 statistical software. Relative risks and 95% confidence intervals were determined, and Z test was used to measure the significance of the overall effect size. A total of nine eligible cohort studies were included in this meta-analysis. The expression of CDH17 in patients with diffuse GC was significantly higher than in those with intestinal-type GC. Moreover, the tumor depth of invasion differed significantly between patients with positive CDH17 (CDH17+) and negative CDH17 (CDH17-) GC. However, there were no significant differences between CDH17+ and CDH17- GC patients with respect to tumor node metastasis clinical stages, histological grades, or lymph node metastasis. Despite the differences in invasive depth, there was no significant difference in 5-year survival rates between CDH17+ and CDH17- GC patients. Our meta-analysis provides evidence that CDH17 protein expression may be associated with the development of GC, suggesting that CDH17 is an important biomarker that could be useful for the early diagnosis of GC. However, CDH17 levels do not appear to impact overall survival.
Highlights
Gastric cancer (GC) is the fourth most common cancer and the second main cause of cancer-related deaths worldwide [1,2]
This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC)
Inclusion and exclusion criteria After carefully reading the abstracts and full articles, studies were included if they met the following inclusion criteria: 1) the study was a non-randomized clinical cohort trial investigating the correlation between CDH17 protein expression and the clinicopathological features and/or prognosis of GC; 2) the study enrolled patients diagnosed with sporadic GC, which was confirmed by histopathologic examinations using tissue samples for CDH17 detection collected from the edge of the tumor; 3) the article
Summary
Gastric cancer (GC) is the fourth most common cancer and the second main cause of cancer-related deaths worldwide [1,2]. Epidemiological evidence shows that GC has become the fourth most common cancer in men (after lung, prostate, and colorectal cancers) and the fifth in women (after breast, colorectal, cervical, and lung cancers). The most important clinicopathologic prognostic factors for GC are tumor location, depth of tumor invasion, and lymph node involvement [7]. Prospective studies demonstrated that the interaction between genetic and environmental factors may be involved in the etiology of GC [8,9]. Several intrinsic genetic factors such as expression of the cadherin-17 gene (CDH17) have been implicated in the carcinogenesis and progression of human cancers, and have become a popular research topic [10]. Some studies suggested that CDH17 participates in tumor invasion and metastasis and may be a valuable marker for the diagnosis and evaluation of GC [11,12]
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Schedule a callMore From: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
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