Correlation of anterior chamber parameters and intraocular pressure with white-to-white corneal diameter in myopic eyes.

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To investigate the correlation between anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV), and IOP with white-to-white (WTW) corneal diameter in myopic eyes. This prospective study conducted at Qassim University, included 163 myopic eyes. Refraction was measured using an autorefractometer, axial length (AL) using IOL Master, and anterior chamber parameters, WTW corneal diameter, and central corneal thickness (CCT) using Pentacam. IOP was assessed with a non-contact tonometer. Correlation analysis was used to assess associations between measured parameters and WTW corneal diameter. For myopic eyes (spherical equivalent: -3.90 ± 1.75 D), mean ocular parameters were: ACD 3.18 ± 0.23mm, ACA 40.02 ± 3.75°, ACV 194.19 ± 18.75mm³, IOP 18.9 ± 2.90 mmHg, and WTW 12.06 ± 0.38mm. Bivariate analysis showed WTW corneal diameter positively correlated with ACD, ACV, ACA, AL, CCT, and IOP (P < 0.001). Multiple regression revealed age, myopia severity, AL, and CCT explained 43.6% of WTW variance, 32.7% in ACD, 26.7% in ACA, 23.0% in ACV, and 47.1% in IOP. Age was positively associated with WTW, ACA, and ACV (P < 0.001). Myopia severity was negatively associated with ACA and positively with ACV (P < 0.05). AL correlated positively with WTW, ACD, ACA, and IOP (P < 0.05), while CCT was significantly associated with most parameters (P < 0.05). Larger WTW corneal diameter predicts deeper anterior chamber and higher IOP in myopic eyes. High myopia shows posterior eye segment expansion with limited anterior growth, and an age-related changes indicate structural remodeling during ongoing myopia progression differs from classical physiological patterns. These findings underscore the importance of WTW corneal diameter as a significant predictor of ocular biometry and refractive development, particularly in young populations with progressing myopia.

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  • Research Article
  • Cite Count Icon 52
  • 10.1111/j.1755-3768.2008.01446.x
Evaluation of anterior segment parameter changes using the Pentacam after uneventful phacoemulsification
  • Jul 13, 2010
  • Acta Ophthalmologica
  • Selim Doganay + 3 more

This study set out to evaluate the influences of uneventful phacoemulsification on the anterior segment parameters obtained with the Pentacam rotating Scheimpflug camera and intraocular pressure (IOP). A total of 42 eyes of 34 patients (26 men, eight women) were evaluated preoperatively, and at 1, 3 and 6 months postoperatively with the Pentacam. Intraocular pressure was measured with the Goldmann applanation tonometer. The non-parametric paired t-test was used to compare preoperative and 1-, 3- and 6-month postoperative measurements of anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), the central 3-, 5- and 7-mm corneal volume (CV), pupil size, and IOP. Pearson's correlation test was used to evaluate the relationships between IOP and ACD, ACV and ACA width. The differences between ACD, ACV, ACA and IOP values taken preoperatively and those taken postoperatively at 1, 3 and 6 months were statistically significant (p<0.05). The differences between CCT, central 3-, 5- and 7-mm CV, and pupil size measurements taken preoperatively and those taken postoperatively at 1, 3 and 6 months were not statistically significant (p>0.05). The decrease in IOP was not correlated with the changes in ACD, ACV and ACA (p>0.05). Uneventful phacoemulsification significantly reduced IOP, increased ACD and ACV, and widened the ACA. However, alterations in CV, CCT and pupil size values were not statistically significant. Alterations in ACD, ACV, ACA and IOP remain stable after the first month of surgery.

  • Research Article
  • 10.7759/cureus.94271
Assessment of Peripapillary Retinal Nerve Fibre Layer Thickness, Optic Nerve Head Rim Area, Anterior Chamber Parameters, and Axial Length in Myopic Eyes
  • Oct 10, 2025
  • Cureus
  • Majid A Moafa + 9 more

Background: Myopic eyes commonly show structural changes, including optic nerve head (ONH) and altered anterior chamber parameters.Aim: The study aimed to investigate the associations of peripapillary retinal nerve fibre layer (RNFL) thickness, optic disc rim area, anterior chamber parameters, and axial length in myopic eyes.Methods: This cross-sectional study was conducted at the Royal Commission Medical Centre, Yanbu, Saudi Arabia, between February and May 2025 and included 152 myopic eyes. Refraction was measured using an autorefractometer. Swept-source optical coherence tomography (SS-OCT) scans (optic disc cube 200 × 200) were used to assess peripapillary RNFL thickness and optic disc rim area. Corneal and anterior chamber parameters, along with axial length, were measured using Pentacam AXL (OCULUS Optikgeräte GmbH, Wetzlar, Germany). Data analysis was conducted to assess the correlation between myopia severity and structural ocular changes.Results: Myopic eyes (mean spherical equivalent: -2.02 ± 1.34 D) showed a significant inverse correlation with both central corneal thickness (r = -0.193, P < 0.05) and corneal thickness at the thinnest point (r = -0.225, P < 0.05). Anterior chamber volume (r = 0.266, P < 0.001) and anterior chamber depth (r = 0.259, P < 0.001) showed significant positive correlations with myopia, while the anterior chamber angle showed no significant association (P > 0.05). Axial length was strongly correlated with myopia severity (r = 0.545, P < 0.001). Inverse correlations were observed between myopia and both peripapillary RNFL thickness (r = -0.100, P > 0.05) and ONH rim area (r = -0.134, P > 0.05). A statistically significant inverse correlation was found between peripapillary RNFL thickness and axial length (r = -0.163, P < 0.05), as well as between ONH rim area and axial length (r = -0.167, P < 0.05).Conclusion: The study revealed a significant positive correlation between myopia and both anterior chamber volume and anterior chamber depth, while the anterior chamber angle remained unaffected. The increase in myopia severity was correlated with thinning of the peripapillary RNFL and a reduction in ONH rim area. These findings underscore the importance of assessing axial elongation and structural changes in myopic eyes, particularly in the context of ocular diseases such as glaucoma, myopic macular degeneration, and retinal detachment.

  • Research Article
  • Cite Count Icon 1
  • 10.3760/cma.j.cn112142-20211222-00597
Correlation between corneal refractive power and anterior chamber morphology in age-related cataract patients with shallow anterior chambers
  • May 11, 2022
  • [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • Fei Yang + 1 more

Objective: To investigate the relationship between corneal refractive power and anterior chamber parameters in age-related cataract patients with normal axial lengths and shallow anterior chambers. Methods: Retrospective case series study. Clinical data of 627 age-related cataract patients (627 eyes) with axial lengths between 22 mm and 24 mm and anterior chamber depths less than 2.20 mm treated in the Department of Ophthalmology of Peking University International Hospital from June 2018 to October 2021 were selected. There were 215 male patients and 412 female patients, with an average age of (75±10) years. According to the average corneal refractive power, eyes were divided into groups of keratometry (K)<42 diopters (D) (50 eyes), 42 D ≤K<45 D (398 eyes) and K ≥45 D (179 eyes). Axial length, anterior chamber depth, corneal diameter, anterior chamber volume and anterior chamber angle of 3 groups were recorded, and Spearman correlation analysis was used to analyze the correlation between parameters. The differences of parameters among different groups were compared by one-way analysis of variance or Kruskal-Wallis test, and multiple or pairwise comparisons using LSD-t test or Mann-Whitney U test. Results: There was a negative correlation between axial length and corneal refractive power in 627 eyes (r=-0.62, P<0.001). Corneal refractive power was positively correlated with anterior chamber depth (r=0.26, P=0.006), while in the K≥45 D group, corneal refractive power was also positively correlated with anterior chamber depth (r=0.23, P=0.025). Anterior chamber depth [M (Q1,Q3)] was 1.77 (1.64, 1.90) mm in the K<42 D group, 1.85 (1.70, 2.14) mm in the 42 D≤K<45 D group and 2.02 (1.81, 2.18) mm in the K≥45 D group. Multiple comparisons showed that there were significant differences in anterior chamber depth between the K<42 D group and the K≥45 D group, between the 42 D≤K<45 D group and the K≥45 D group (U=14 372.00, 18 226.00; both P<0.05). There was a negative correlation between corneal refractive power and corneal diameter in 627 eyes (r=-0.52,P<0.001), while in the 42 D≤K<45 D group and the K≥45 D group, corneal refractive power were also negatively correlated with corneal diameter (r=-0.20, -0.28; both P<0.05). Corneal diameter was (11.77±0.43) mm in the K<42 D group, (11.24±0.35) mm in the 42 D≤K<45 D group and (10.90±0.33) mm in the K≥45 D group, while there were significant differences in multiple comparisons (t=1.92, 2.96, 2.01; all P<0.05). There was no correlation between corneal refractive power and anterior chamber volume, or between corneal refractive power and anterior chamber angle in 627 eyes (all P>0.05). There was no significant difference both in anterior chamber volume and in anterior chamber angle among 3 groups (all P>0.05). Conclusion: For age-related cataract patients with normal axial lengths and shallow anterior chambers, the anterior chamber depth increase and the corneal diameter decrease with the increase of corneal refractive power, but there is no significant change in anterior chamber volume and anterior chamber angle.

  • Research Article
  • Cite Count Icon 1
  • 10.7717/peerj.19227
Measurements of white-to-white corneal diameter and anterior chamber parameters using the Pentacam AXL wave and their correlations in the adult Saudi population.
  • Apr 1, 2025
  • PeerJ
  • Wafa M Alotaibi + 3 more

Assessment of eye parameters such as the white-to-white (WTW) corneal diameter, anterior chamber depth (ACD), and anterior chamber angle (ACA) are essential for preoperative evaluation of refractive surgery and diagnosing and managing some ocular diseases. To report the distribution and association between white-to-white corneal diameter and anterior chamber parameters in the Saudi adult population. Cross-sectional prospective study consisting of 82 Saudi adults. White-to-white corneal diameter, anterior chamber angle, anterior chamber depth, and axial length were collected from healthy subjects using the Pentacam AXL Wave in a tertiary eye care setting. Mean white-to-white corneal diameter, anterior chamber angle, anterior chamber depth, and axial length were 11.95 ± 0.39 mm, 37.94 ± 5.01°, 2.97 ± 0.31 mm and 23.93 ± 0.97 mm, respectively. A significant moderate correlation was found between white-to-white corneal diameter and anterior chamber angle (r = 0.31, p ≤ 0.01), anterior chamber depth (r = 0.49, p ≤ 0.01), and axial length (r = 0.50, p ≤ 0.01) and between anterior chamber angle and anterior chamber depth (r = 0.71, p ≤ 0.01). Furthermore, age was moderately correlated with anterior chamber angle (r = 0.44, p 0.01) and anterior chamber depth (r = 0.39, p 0.01) and weakly correlated with white-to-white corneal diameter (r =0.17, p = 0.12). Males had a significantly (p < 0.01) higher white-to-white corneal diameter (12.12 ± 0.38 mm) than females (11.84 ± 0.36.mm). Reference values for white-to-white corneal diameter and anterior chamber parameters would help eye care professionals choose the right lenses for cataract and refractive surgeries as well as in diagnosing glaucoma and corneal disorders.

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Comparison of Corneal and Anterior Chamber Parameters between Myopic Eyes and the LASIK – Treated Eyes Using Pentacam
  • Dec 31, 2025
  • Pakistan Journal of Ophthalmology
  • Majid A Moafa

Purpose: To compare the Corneal and Anterior Chamber Parameters between Myopic Eyes and the LASIK-treated eyes Using Pentacam Study Design: Cross sectional observational study Place and duration of study: Department of Optometry, College of Applied Medical Sciences, Qassim University from January 2024 to May 2024. Methods: The study included 173 patients, 83 individuals with low to moderate myopia and 90 post-LASIK patients. Corneal and anterior chamber measurements were taken using Pentacam, including central corneal thickness, anterior and posterior corneal surface power, anterior chamber depth, angle, and volume. Results: The mean spherical equivalent was -2.01 ± 1.02 D in myopic eyes and -0.51 ± 0.41 D in post-LASIK eyes (P = 0.000). Central and thinnest corneal thicknesses were significantly reduced in the post-LASIK group (P = 0.000). Uncorrected visual acuity in post-LASIK eyes (mean 1.03 ± 0.15) was comparable to the best-corrected visual acuity in myopic eyes (P = 0.098). A significant decrease in anterior corneal surface power was noted post-LASIK, while posterior corneal power remained stable. Anterior chamber depth and volume showed modest but significant reductions, with no significant difference in anterior chamber angle between the groups. Conclusion: LASIK leads to significant thinning of the cornea and reduction in anterior corneal power, while posterior corneal curvature remains stable. Minor decreases in anterior chamber depth and volume occur without affecting the chamber angle or visual outcomes.

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  • 10.1080/09286586.2024.2390425
Distribution and Determinants of Anterior Chamber Angle and Anterior Chamber Volume in Young Chinese Adults
  • Aug 19, 2024
  • Ophthalmic Epidemiology
  • Dan-Lin Li + 7 more

Purpose Current study aimed to understand the distribution and determinants of anterior chamber angle (ACA) and anterior chamber volume (ACV) in Chinese young adults, which can help fill current data gaps and aid in early detection and intervention for high-risk population of primary angle closure glaucoma. Methods This cross-sectional study utilized data from 2014 participants who completed questionnaire and eye examination in September 2021. ACV and ACA were measured using a Pentacam tomographer. Spherical equivalent (SE) was evaluated by autorefractor without cycloplegia. Central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were evaluated using Corvis-ST. Axial length (AL), corneal radius (CR), anterior chamber depth (ACD), and white to white were assessed using the IOL Master. Results A total of 1635 students were included in the analysis. The mean ACV and AVA were 194.74 ± 32.30 μL and 38.81 ± 4.84°, respectively. Males have a larger ACV and wider ACA than females. ACV was positively correlated with ACA (r = 0.24, p < 0.001), and the correlation was stronger for non-myopic students than for myopic students. Multivariable linear regression model showed that AL (β = 2.41), CR (β = –4.12), CCT (β = –0.11), ACD (β = 97.93), and bIOP (β = 0.40) were associated with ACV, and CCT (β = –0.01), CR (β = 0.38), and ACD (β = 7.41) were associated with ACA (all p < 0.05). Random forest model indicated that ACD was the most critical predictor of both ACV and ACA. Conclusions This study reported the distribution and determinants of ACA and ACV. Deeper ACD was associated with larger ACV and wider ACA.

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  • 10.3760/cma.j.issn.2095-0160.2016.07.008
The morphologic and quantitative evaluation of ocular anterior chamber parameters after laser peripheral iridotomy in primary angle-closure glaucoma eyes
  • Jul 10, 2016
  • Chinese Journal of Experimental Ophthalmology
  • Xiaoli Liu + 4 more

Background Pentacam anterior segment analysis system(Pentacam) is more accurate in the quantitative evaluation of ocular anterior segment in primary angle-closure glaucoma (PACG) eyes than slit lamp microscope and ultrasound biomicroscope (UBM). However, its accuracy in the earlier stage of PACG before and after YAG laser peripheral iridotomy (LPI) is not fully elucidated. Objective This study was to assess the effect of YAG LPI in PACG patients with Pentacam. Methods A prospective self-controlled study was performed.Thirty-five fellow eyes (pre-clinical stage of PACG) of acute PACG and 35 fellow eyes of chronic PACG were included in the Second Hospital of Hebei Medical University from July, 2012 to December, 2013.YAG LPI was performed on the eyes, and the parameters of ocular anterior segment including central anterior chamber depth (ACD), anterior chamber volume (ACV) and peripheral anterior chamber angle (ACA) were measured and compared by Pentacam before and 1 day, 7 days, 28 days after operation.This study was approved by the Ethic Committee of the Second Hospital of Hebei Medical University and informed consent was obtained from all subjects. Results In pre-clinical stage of PACG eyes, the postoperative ACD and ACV values were increased in comparison with preoperation, showing significant differences among various time points (ACD: F=6.783, P=0.004; ACV: F=19.090, P=0.000), and no significant difference was found in ACA among different time points (F=0.153, P=0.928). In the fellow eyes of chronic PACG, the postoperative ACD and ACV values were larger than those of preoperation, with significant differences among various time points (ACD: F=21.576, P=0.000; ACV: F=47.506, P=0.000), and no significant difference was found in ACA among different time points (F=0.581, P=0.629). The change values of ACD and ACV were (0.064±0.022)mm and (27.840±4.963)mm3 in the eyes of pre-clinical stage of PACG, and those in the fellow eyes of chronic PACG were (0.047±0.020)mm and (21.000±3.278)mm3, showing significant differences between the two groups (ACD: t=2.783, P=0.008; ACV: t=5.749, P=0.000). Conclusions Pentacam allows easy, fast, automatic and non-contact quantification and three-dimension image of the anterior chamber parameters before and after YAG LPI in pre-clinical stage of PACG eyes and fellow eyes of chronic PACG.The ACD deepens and ACV increases after LPI in glaucomous eyes, especially in the pre-clinical stage of PACG eyes. Key words: Glaucoma, angle-closure/surgery; Anterior chamber/pathology; Biometry; Imaging, three-dimensional; Diagnostic techniques, ophthalmological/instrumentation; Laser therapy; Iridectomy; Pentacam anterior segment analysis system

  • Research Article
  • Cite Count Icon 2
  • 10.1007/s40123-022-00608-6
Correlations of Corneal Curvature with Corneal Spherical Aberration and Anterior Chamber Parameters in Eyes with Shallow Anterior Chambers
  • Nov 5, 2022
  • Ophthalmology and Therapy
  • Fei Yang + 1 more

IntroductionThis study aimed to investigate the distribution of corneal spherical aberration (CSA) and the relationship between corneal curvature with CSA and anterior chamber parameters in age-related cataract patients with normal axial lengths and shallow anterior chambers.MethodsPreoperative data of age-related cataract patients were collected in this retrospective comparative study. According to the average corneal curvature, the eyes were divided into groups of Km < 42 diopters (D), 42 D ≤ Km < 45 D, and Km ≥ 45 D. The axial length (AL) and corneal curvature were obtained using IOLMaster. CSA, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and corneal diameter (CD) were acquired according to Pentacam. The above parameters were compared among the three groups. Correlation analysis was applied to these parameters.ResultsThe average CSA value of 753 eyes was 0.41 ± 0.27 μm, with no significant difference among the three groups. Overall, CSA was significantly correlated with corneal curvature and ACD. The comparison of ACD among the three groups showed significant differences between the Km ≥ 45 D group, Km < 42 D group, and 42 D ≤ Km < 45 D group. Corneal curvature was positively correlated with ACD, and further analysis confirmed that the relationship was significant only in the Km ≥ 45 D group. There were statistically significant differences in CD between the three groups. A significant correlation was found in corneal curvature and CD in all eyes, which was also found in the 42 D ≤ Km < 45 D group and the Km ≥ 45 D group. Concerning ACV and ACA, no correlation with corneal curvature was found. In addition, the mean ACV and ACA of the three groups did not show any significant difference.ConclusionsCSA was higher in this population and had individual variance. Compared with ACD, ACV and ACA were more stable in different corneal curvatures and more objective in representing the anterior chamber space.

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  • Cite Count Icon 32
  • 10.3341/kjo.2015.29.4.220
Evaluation of Anterior Segment Parameters in Obesity
  • Jul 21, 2015
  • Korean Journal of Ophthalmology : KJO
  • Alime Gunes + 3 more

PurposeTo investigate anterior segment parameters in obese patients in comparison to healthy individuals.MethodsThirty-four obese subjects and 34 age-sex-matched healthy subjects were enrolled in this prospective cross-sectional study. Ophthalmological examinations including intraocular pressure (IOP), central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and axial length (AL) measurements were performed on each subject. Height and weight of all subjects were recorded and body mass index (BMI) was calculated.ResultsIOP was significantly higher in the obese group (p = 0.003). The mean ACD in obese subjects was significantly lower than that in control subjects (p = 0.036). AL, ACV, ACA and CCT were not significantly different between the groups. There was a positive correlation between BMI and IOP (r = 0.404, p < 0.001). ACD and ACA were negatively correlated with BMI.ConclusionsIOP was significantly higher and ACD was significantly lower in obese subjects. AL, ACV, ACA and CCT were not significantly different between the groups. The impact of obesity on anterior chamber parameters should be further investigated.

  • Research Article
  • Cite Count Icon 2
  • 10.3906/sag-1203-92
Anterior segment morphometry and intraocular pressure change after uneventful phacoemulsification
  • Jan 1, 2013
  • Turkish Journal of Medical Sciences
  • Tamer Takmaz + 2 more

To evaluate the changes in anterior segment morphometry and intraocular pressure (IOP) with 3D rotating Scheimpflug camera-topography system after uneventful phacoemulsification. Materials and methods: In 56 eyes of 54 patients, anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and central corneal thickness (CCT) were measured with the Sirius 3D Rotating Scheimpflug camera-topography system preoperatively and 1 month after surgery. IOP was measured with applanation tonometer. The preoperative and postoperative results were compared. Results: Preoperative and postoperative anterior segment parameters were as follows: ACD 2.7 ± 0.4 and 3.5 ± 0.3 mm, ACV 143.6 ± 48.8 and 192.4 ± 59.5 mm3, nasal ACA 42.3 ± 8.4° and 53.0 ± 4.5°, temporal ACA 36.9 ± 11.9° and 45.8 ± 13.2° (P < 0.001). CCT, iris diameter, and pupil diameter changes were not statistically significant (P > 0.05). Mean axial length (AL) was 23.4 ± 0.8 mm. The IOP and corrected IOP were 14.6 ± 3.5 and 14.5 ± 3.9 preoperatively and 10.4 ± 2.4 and 10.0 ± 3.3 mmHg postoperatively (P < 0.001). There was not a correlation between AL and IOP, ACD, ACV, or ACA, and no correlation was found between IOP change and ACD, ACV, or ACA (P > 0.05). Conclusion: Measurements confirm that after uneventful phacoemulsification, IOP decreases while ACD, ACV, and ACA increase. Preoperative AL and IOP changes did not correlate with ACD, ACV, and ACA.

  • Research Article
  • Cite Count Icon 13
  • 10.1097/ijg.0000000000000890
Distribution of Anterior Chamber Parameters in Normal Chinese Children and the Associated Factors.
  • Apr 1, 2018
  • Journal of Glaucoma
  • Jing Wang + 6 more

To describe the distribution of anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) and establish the associated factors in the pediatric population in Shanghai, China. In this cross-sectional study, children aged 6 to 18 years from 9 primary and middle schools in Shanghai were enrolled. The Pentacam Scheimpflug camera was used to measure anterior eye chamber parameters. The distribution of ACD, ACV, ACA, and their associations with age, sex, body mass index, cycloplegic refractive error, axial length, intraocular pressure, and other parameters were analyzed. A total of 1321 children were included, with a mean age of 9.65±2.95 years. The mean ACA, ACD, and ACV values were 37.95±7.96 degrees, 3.22±0.23 mm and 194.89±28.95 mm, respectively, and were higher in boys than in girls. ACV and ACD had similar growth trend curves with age, whereas ACA was stable. Overall, 5% of the tested children had ACA values ≤24.91 degrees. Greater ACV, deeper ACD, shorter pupil diameter, shorter axial length, and thinner apex corneal thickness were the independent factors associated with wider ACA (R=13.0%, P<0.001). As one of diagnostic indicators of angle closure, ACA was stable with age. The results of this study should improve the current understanding of the distribution of anterior chamber parameters and the main factors affecting their variation.

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  • Cite Count Icon 1
  • 10.3109/15569527.2010.523036
Evaluation of the effect of tolterodine on pupil diameter and anterior chamber parameters with the Pentacam
  • Oct 19, 2010
  • Cutaneous and Ocular Toxicology
  • Altan Goktas

Background: To evaluate the effect of tolterodine on pupil diameter and anterior chamber parameters, including volume, depth, and angle, with the Pentacam.Methods: The 56 eyes of 28 patients who were diagnosed as having overactive bladder and planned to be treated with tolterodine were followed up prospectively in the study. All the patients underwent full ophthalmic examination and scanning with the Pentacam (Oculus, Inc., Wetzlar, Germany) before and 4 weeks after the start date of tolterodine therapy. In addition, the 30 eyes of 15 healthy volunteers were analyzed twice as a control group for repeatability of the measurements.Results: The quantitative descriptors of the anterior chamber before and after the treatment, respectively, were as follows: pupil diameter, 3.02 ± 0.56 mm and 3.01 ± 0.55 mm; anterior chamber depth, 2.74 ± 0.35 mm and 2.75 ± 0.34 mm; anterior chamber volume, 150.23 ± 33.95 mm3 and 150.27 ± 34.48 mm3; and anterior chamber angle, 34.56° ± 5.68° and 35.03° ± 5.99°. For all the measurements, the differences did not reach statistical significance (p > .05). Also, the comparison of the same parameters obtained from the first and second measurements of healthy volunteers was not statistically significant (p > .05).Conclusion: Our study demonstrates that tolterodine does not affect pupil diameter and anterior chamber parameters, including angle, volume, and depth. Most likely, it is an organ-selective agent, inhibiting muscarinic receptors in the bladder rather than in the anterior segment of the eye.

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  • Research Article
  • Cite Count Icon 2
  • 10.1155/2018/8646275
Anterior Chamber Angle and Volume Do Not Change after Myopic Laser-Assisted In Situ Keratomileusis in Young Patients
  • Dec 10, 2018
  • Journal of Ophthalmology
  • Ertuğrul Tan Yassa + 1 more

Purpose We aimed to investigate whether anterior chamber angle, depth, and volume change after myopic laser-assisted in situ keratomileusis (LASIK) in young patients. Methods This retrospective study included 29 eyes of 29 patients (15 females and 14 males) between the ages of 18 and 39 years who underwent LASIK for the treatment of myopia. In addition to complete ophthalmic examination, anterior chamber angle (ACA), central anterior chamber depth (ACD), and anterior chamber volume (ACV) were measured by using a Sirius rotating Scheimpflug camera combined with Placido disc corneal topography (CSO, Florence, Italy). Preoperative and postoperative values were compared using paired t-tests. Linear regression was used to evaluate the relationship between changes in refraction and changes in ACA, ACD, and ACV as well as between attempted maximum ablation depth and changes in ACA, ACD, and ACV. Results The mean age of the study population was 25.5 ± 6.2 years. The mean preoperative and postoperative spherical equivalent values were −3.30 ± 1.92 D and −0.18 ± 0.29 D, respectively. ACV and ACA were not significantly changed after surgery; however, central ACD was significantly decreased (preoperatively = 3.366 ± 0.316 mm vs postoperatively = 3.3 ± 0.298 mm) with a mean difference of 0.066 ± 1.121 mm. There were no significant relationships between changes in refraction and anterior segment dimensions or between attempted maximum ablation depth and anterior segment dimensions. Conclusion Measurements with Sirius showed that ACA and ACV did not change; however, central ACD significantly decreased after myopic LASIK in young patients, indicating that the preoperative central ACD value should not be used interchangeably with the postoperative central ACD value.

  • Research Article
  • 10.3760/cma.j.issn.2095-0160.2019.11.010
Analysis of anterior chamber morphological changes after small incision lenticule extraction
  • Nov 10, 2019
  • Chinese Journal of Experimental Ophthalmology
  • Yaohua Zhang

Objective To investigate the changes of anterior chamber profiles after small incision lenticule extraction(SMILE) and analyze the possible influencing factors. Methods A case observation study was designed.Thirty-one patients(59 eyes) with myopia and myopic astigmatism who underwent SMILE surgery at the Refractive Surgery Center of Tianjin Eye Hospital from April to December 2015 were enrolled and examined preoperatively and at 1 month, 3 and 6 months postoperatively.The anterior chamber profiles, including anterior chamber depth (ACD), anterior chamber volume (ACV) and anterior chamber angle (ACA) were measured using the Pentacam.The correlations between parameters were analyzed and the differences of the parameters at different time points were compared.This study followed the Declaration of Helsinki.This study protocol was approved by Ethic Committee of Tianjin Eye Hospital (No.TJYYLL-2015-20). Written informed consent was obtained from each subject before the operation. Results Compared with pre-operation, the central corneal thickness (CCT) was significantly decreased at 1 month, 3 and 6 months postoperatively (all at P 0.05). The posterior corneal elevation (PCE) at different time points before and after surgery was significantly different (F=19.249, P<0.001), compared with the preoperation, the PCE at 1 month, 3 and 6 months postoperatively moved slightly backward (all at P<0.05). The preoperative ACD was (3.33±0.25)mm, the preoperative ACV was (217.46±31.55)mm3, and the ACD was (3.31±0.25), (3.30±0.25) and (3.30±0.25)mm, the ACV was (214.71±33.09), (211.14±33.65) and (210.08±32.19)mm3, respectively at 1 month, 3 and 6 months postoperatively, with significant differences at different time points before and after surgery (F=12.477, 12.205; both at P<0.001), compared with the preoperation, the ACD at 1 month, 3 and 6 months postoperatively and ACV at 3 months and 6 months postoperatively were obviously decreased, with a significant difference between them (all at P<0.05). There was a significant positive correlation between ACD and ACV at different time points before and after surgery (r=0.870, 0.893, 0.886, 0.884; all at P<0.001). The preoperative ACD was negatively correlated with CCT (r=-0.286, P<0.05). Conclusions The ACD is decreased postoperatively, it is basically stable at (3.30±0.25)mm, which satisfies the requirements of the ACD required for implantable collamer lens.And the stable state of ACD is also important for keratoconus detection. Key words: Small incision lenticule extraction; Anterior chamber depth; Anterior chamber volume; Anterior chamber angle

  • Research Article
  • Cite Count Icon 25
  • 10.1007/s40123-019-0187-5
The Effect of Cycloplegia on the Ocular Biometric and Anterior Segment Parameters: A Cross-Sectional Study.
  • May 3, 2019
  • Ophthalmology and Therapy
  • Hamed Momeni-Moghaddam + 6 more

IntroductionTo evaluate the effects of cycloplegia on the biometric components and anterior segment parameters of the eye.MethodsIn this cross-sectional study, changes to axial length (AL), anterior chamber depth (ACD) lens thickness, anterior chamber angle (ACA) and volume, corneal thickness in the pupil center (PC), corneal curvature (CC) and white-to-white (WTW) following cycloplegia induced by tropicamide 1% in 42 eyes of patients aged 23–58 years were assessed. Biometric components and anterior segment parameters were measured using an IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany) and a Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany), respectively.ResultsSignificant statistical changes in ACD (increased by 0.06 ± 0.05 mm; p < 0.001), anterior chamber volume (increased by 15.19 ± 10.32 mm3; p < 0.001), ACA (decreased by 2.18 ± 10.20°; p = 0.029) and lens thickness (decreased by 0.02 ± 0.03 mm; p < 0.001) were observed post-cycloplegia, while the changes in CC, corneal thickness in the PC, WTW and AL were not statistically different (p > 0.05). Also, a significant inferior displacement of the PC along the vertical axes was seen (p = 0.020).ConclusionCycloplegia resulted in a deeper ACD and thinner lens thickness. These changes should be considered in determining intraocular lens (IOL) power to prevent refractive surprises in cataract surgery and also in the phakic IOL implantation.

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