Abstract
Umbilical artery flow velocity waveforms (UAFVW's) were measured by Doppler ultrasound in 35 pregnant women with pregnancy induced hypertension. The stable hydration products of the vasoconstrictor and proaggregatory thromboxane A 2 and vasodilatory and anti-aggregatory prostacyclin (i.e. thromboxane B 2 (TxB 2) and 6 ketoprostaglandin F 1 α (6 keto PGF 1 α ) respectively) were measured in blood obtained from the umbilical vein and were assayed by radioimmunoassay. Abnormal umbilical artery Resistance Index (UARI) was associated with higher thromboxane B 2 levels, lower 6-ketoprostaglandin F 1 α levels and lower 6-keto PGF 1α TxB 2 ratio. Moreover, the umbilical artery Resistance Index was significantly correlated with the 6-keto PGF 1α thromboxane B 2 ratio suggesting an association between abnormal umbilical artery blood flow and altered prostacyclin/thromboxane balance in the fetoplacental compartment in patients with pregnancy induced hypertension (PIH).
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