Abstract
Lung cancer is one of the leading causes of death worldwide. Lung cancer treatment are including surgery, chemotherapy, targeted therapy and radiotherapy. Despite therapy modalities mentioned above, lung cancer survival is remained poor. In this research we want to find out the correlation between the current treatment modalities used and the survival of lung cancer patients. Data source is secondary data collected from electronic medical records in oncology polyclinic of Dr. Soetomo General Academic Hospital. Data will be analyzed regarding the correlation between the therapy given and survival of the patients also the correlation between histologic types of lung cancer and therapy given using contingency coefficient. Coefficient we found weak correlation between cancer type and therapy modalities given (p<0.01 and C=0.301) where targeted therapy is related with adenocarcinoma. Moderate correlation between therapy given and survival of the patients (p<0.01, C=0.533). Targeted therapy related with better survival outcome compared to chemotherapy and patient that get only supportive care. Targeted therapy is related with better prognosis compared to chemotherapy and supportive care. Targeted therapy drugs that used in Adenocarcinoma found in this research is mainly targeting EGFR mutation. Squamous cell carcinoma and small-cell carcinoma mainly treated using platinum-based chemotherapy.
Highlights
Lung cancer is malignancies in lung that originates from lung parenchyma or bronchial epithelium [1]
Targeted therapy is related with better prognosis compared to chemotherapy and supportive care
Targeted therapy drugs that used in Adenocarcinoma found in this research is mainly targeting EGFR mutation
Summary
Lung cancer is malignancies in lung that originates from lung parenchyma or bronchial epithelium [1]. According to the histological aspect, lung cancer is divided into 2 types, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Non-small cell lung cancer further divided into adenocarcinoma, squamous cell carcinoma and large cell carcinoma [3]. Lung cancer treatment are including surgery, chemotherapy, targeted therapy and radiotherapy. Surgery are used as first treatment in early stage non-small cell lung cancer [4]. 5-year survival rate when diagnosed in late stage is only around 1% [8].In this research we want to find out the correlation between the current treatment modalities used and the survival of lung cancer patients Despite therapy modalities mentioned above, lung cancer survival is remained poor, especially for late stage lung cancer. 5-year survival rate when diagnosed in late stage is only around 1% [8].In this research we want to find out the correlation between the current treatment modalities used and the survival of lung cancer patients
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