Abstract
BackgroundSmall dense low-density lipoprotein cholesterol (sdLDL-C) concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity. We examined whether SdLDL-C is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and traditional CVD risk factors in Chinese healthy subjects.MethodsWe measured CA-IMT, blood pressure (BP), sdLDL-C, glucose metabolism and lipid in 183 native Chinese healthy subjects. CA-IMT was assessed by ultrasonography, and sdLDL-C concentrations were measured by a homogenous assay. Pearson's correlation coefficient analyses and Multiple regression analyses were used to examine the relationships between CA-IMT values and other clinical variables.ResultsThe sdLDL-C level was significantly higher in males than in females (p <0.05) and there was an age effect on sdLDL-C (p <0.05). When the effects of age, gender and other traditional CVD risk factors were adjusted using multiple regression analysis. CA-IMT remained significantly associated with sdLDL-C(β = 0.437, p <0.001).ConclusionsThere are gender and age differences in sdLDL-C levels among a healthy Chinese population. Moreover, we found adjusted traditional CVD risk factors such as higher age, male sex, and other traditional CVD risk factors, the association between CA-IMT and SdLDL-C remained significant. sdLDL-C is may be a useful predictor in the assessment of CA-IMT in Chinese population.
Highlights
Small dense low-density lipoprotein cholesterol concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity
The purpose of this study is to evaluate whether the quantitative measurement of SdLDL-C gives better information in CVD risk assessment than standard Low-density lipoprotein (LDL)-C and other lipid variables using carotid artery intima-media thickness (CA-IMT) as a surrogate measure of atherosclerosis
Results Small dense low-density lipoprotein cholesterol (sdLDL-C) and various parameters in the study subjects One hundred eighty-three subjects were classified into males group and females group
Summary
Small dense low-density lipoprotein cholesterol (sdLDL-C) concentration was useful in the assessment of the presence of cardiovascular diseases (CVD) and its severity. Compared with lbLDL, small dense LDL cholesterol (sdLDL-C) is thought to be more atherogenic [3]. Shen et al Lipids in Health and Disease (2015) 14:137 instrumentation required for NMR is too expensive for general clinical laboratories to acquire feasibly. A new fully automated homogenous assay for measuring sdLDL-C was being used, and sdLDL-C values showed excellent agreement with the sdLDL isolation by sequential ultracentrifugation [14]. This precise and rapid method allows for the routine of large number of samples
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