Correlation between serum lipids and 1-hour postload plasma glucose levels in normoglycemic individuals

Abstract

One-hour plasma glucose (1-h PG) level of ≥ 155mg/dL during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes mellitus among individuals with normal glucose tolerance (NGT). In addition, high triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C) levels are risks factors for development of diabetes mellitus in the future. To examine the association between 1-h PG levels and serum lipid profiles in individuals with NGT. We enrolled 736 individuals with NGT who underwent a 75-g OGTT. They were divided into 2 groups, those with 1-h PG levels < 155mg/dL (n=543) and those with 1-h PG levels ≥ 155mg/dL (n=193). Multivariate linear regression analyses were performed to assess correlations between 1-h PG levels and lipid profiles. The multiple linear regression analyses showed that 1-h PG levels negatively correlated with HDL-C in individuals with NGT who had 1-h PG levels ≥ 155mg/dL as well as those with 1-h PG levels < 155mg/dL (β=-0.137, P=.001 and β=-0.214, P=.003, respectively). In addition, 1-h PG levels positively correlated with log-transformed TG/HDL-C ratio in both groups (β=0.098, P=.032 and β=0.152, P=.035, respectively). Moreover, even after adjusting for confounding parameters, TG was higher and HDL-C was lower in individuals with NGT who had 1-h PG levels ≥ 155mg/dL compared with those who had 1-h PG levels < 155mg/dL. HDL-C levels and TG/HDL-C ratios closely correlate with 1-h PG levels in individuals with NGT.