Abstract
Objective: Published literature remains inconclusive as to the significance, and predictors of zona pellucida thickness. Current treatment strategies involve the use of assisted hatching (AH) for women of older reproductive age and/or with elevated FSH levels. This strategy assumes that these women are at increased risk for thickened zona pellucida and would benefit from AH. To test the hypothesis that zona pellucida thickness correlates with maternal age, day 3 follicle-stimulating hormone (FSH), and/or average peak estradiol per follicle, we performed a retrospective analysis of all embryos transferred between November 2001 and May 2002 at the University of California, San Francisco Center for Reproductive Medicine.
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